一种从链霉菌中获取γ-丁内酯自动调节因子的模块化有机催化方法。
A modular and organocatalytic approach to gamma-butyrolactone autoregulators from Streptomycetes.
作者信息
Elsner Petteri, Jiang Hao, Nielsen Johanne B, Pasi Filippo, Jørgensen Karl Anker
机构信息
Danish National Research Foundation: Center for Catalysis, Department of Chemistry, Aarhus University, Aarhus C, DK-8000, Denmark.
出版信息
Chem Commun (Camb). 2008 Nov 30(44):5827-9. doi: 10.1039/b812698d. Epub 2008 Oct 3.
A general synthesis of optically active gamma-butyrolactone autoregulators is developed by a two-step sequence to assemble 2,3-trans-disubstituted butyrolactones in high yields and enantioselectivities; the scope of this reaction was elaborated by setting up a library of alkyl-substituted butyrolactones and the synthesis of the autoregulators IM-2 and VB-D.
通过两步反应序列开发了一种光学活性γ-丁内酯自调控剂的通用合成方法，以高产率和对映选择性组装2,3-反式二取代丁内酯；通过建立烷基取代丁内酯库以及自调控剂IM-2和VB-D的合成来阐述该反应的适用范围。
Zotero 插件