State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, P. R. China.
Chem Asian J. 2012 Oct;7(10):2411-8. doi: 10.1002/asia.201200467. Epub 2012 Jul 16.
An efficient nickel(0)-catalyzed highly regio- and stereoselective hydrocarboxylation of homopropargylic alcohols with ZnEt(2) in the presence of CO(2) (1 atm, balloon) to synthesize α-alkylidene-γ-butyrolactones is described. The catalyst is highly active and can be applied for the synthesis of (optically active) mono- or bicyclic α-alkylidene-γ-butyrolactones with excellent regio- and stereoselectivity and good functional group tolerance. The potential of the reaction has been demonstrated in the first synthesis of (±)-heteroplexisolide E.
描述了一种高效的镍(0)催化的、高度区域和立体选择性的偕丙醇与 ZnEt(2)在 CO(2)(1 大气压，气球)存在下的氢羧化反应，以合成α-亚烷基-γ-丁内酯。该催化剂具有很高的活性，可用于合成（光学活性）单环或双环α-亚烷基-γ-丁内酯，具有优异的区域和立体选择性以及良好的官能团耐受性。该反应的潜力已在（±）-heteroplexisolide E 的首次合成中得到证明。
