多价糖结构的模块化合成及其独特的选择素结合行为。
Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior.
作者信息
Papp Ilona, Dernedde Jens, Enders Sven, Haag Rainer
机构信息
Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195, Berlin, Germany.
出版信息
Chem Commun (Camb). 2008 Nov 30(44):5851-3. doi: 10.1039/b813414f. Epub 2008 Oct 3.
DOI:10.1039/b813414f
PMID:19009103
Abstract
Hyperbranched polyglycerols (HPGs) are ideal scaffolds for the multivalent presentation of saccharides, due to their biocompatible, carbohydrate-like properties; here, we report the conjugation of galactosesugar moieties to HPG, and the multivalent effect of these constructs on selectin binding.
摘要
超支化聚甘油（HPGs）因其具有生物相容性、类似碳水化合物的特性，是糖类多价展示的理想支架；在此，我们报告半乳糖糖基与HPG的缀合，以及这些构建体对选择素结合的多价效应。
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