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病例报告:一名儿童尤因肉瘤切除术后16厘米骨干缺损的重建

Case report: reconstruction of a 16-cm diaphyseal defect after Ewing's resection in a child.

作者信息

Biau David Jean, Pannier Stéphanie, Masquelet Alain Charles, Glorion Christophe

机构信息

Assistance Publique-Hôpitaux de Paris, Service de chirurgie orthopédique et traumatologique, Hôpital Cochin, 27, rue du Faubourg Saint-Jacques, 75679, Paris Cedex 14, France.

出版信息

Clin Orthop Relat Res. 2009 Feb;467(2):572-7. doi: 10.1007/s11999-008-0605-9. Epub 2008 Nov 14.

Abstract

Numerous options exist for intercalary segmental reconstruction after bone tumor resection. We present the extension of a recently developed surgical two-stage technique that involves insertion of a cement spacer, induction of a membrane, and reconstruction of the defect with cancellous and cortical bone autograft in a 12-year-old child. The boy was referred to our center for treatment of a right femoral diaphyseal Ewing's sarcoma. The first stage involved resection of the tumor and reconstruction with a locked intramedullary nail and a polymethylmethacrylate cement spacer. Seven months after the initial procedure during which adjuvant chemotherapy was given, the second-stage procedure was performed. The cement was removed and cancellous and cortical bone autograft was grafted in the membrane created around the cement spacer. Touchdown weightbearing was allowed immediately, partial weightbearing was resumed 6 weeks after the operation, and full weightbearing was allowed 4 months later. Successive plain radiographs showed rapid integration of the autograft to the host bone with bone union and cortical reconstitution. The principle of the induced membrane reconstruction seems applicable to intercalary segmental reconstruction after bone tumor resection in children.

摘要

骨肿瘤切除术后节段性重建有多种选择。我们展示了一种最近开发的手术两阶段技术的扩展应用,该技术包括植入骨水泥间隔物、诱导形成膜以及用松质骨和皮质骨自体骨重建缺损,应用于一名12岁儿童。该男孩因右股骨干尤文肉瘤被转诊至我们中心治疗。第一阶段包括切除肿瘤并用带锁髓内钉和聚甲基丙烯酸甲酯骨水泥间隔物进行重建。在进行初始手术并给予辅助化疗7个月后,进行了第二阶段手术。取出骨水泥,将松质骨和皮质骨自体骨植入在骨水泥间隔物周围形成的膜内。术后立即允许触地负重,术后6周恢复部分负重,4个月后允许完全负重。连续的X线平片显示自体骨与宿主骨迅速融合,实现骨愈合和皮质重建。诱导膜重建的原则似乎适用于儿童骨肿瘤切除术后的节段性重建。

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