Knottnerus J A
Ned Tijdschr Geneeskd. 2008 Oct 11;152(41):2216-8.
The increasingly strong interaction between biomedical and epidemiological research is one of the most important steps forward in medicine and public health since World War II. Crucial breakthroughs were the development of powerful observational epidemiological studies, the introduction of convincingly designed clinical trials, and meta-analyses to objectively summarise the results of multiple studies. For this progress, the work of Sir Richard Peto (born in 1943), epidemiologist and statistician at the University of Oxford, Great Britain, has been essential. Peto combined innovative methodological contributions with large-scaled empirical studies, often based on worldwide collaborations, with a special focus on smoking and health, treatment of breast cancer, and cholesterol-lowering interventions. His work both produced and evoked an impressive evidence base to improve clinical and public health practice. In accordance with the advice of a selection committee of the Royal Netherlands Academy of Arts and Sciences, he was awarded the Dr A.H. Heineken Prize for Medicine on 2 October 2008.
生物医学研究与流行病学研究之间日益紧密的互动，是自第二次世界大战以来医学和公共卫生领域最重要的进展之一。关键突破包括强大的观察性流行病学研究的发展、设计令人信服的临床试验的引入，以及用于客观总结多项研究结果的荟萃分析。对于这一进展，英国牛津大学的流行病学家兼统计学家理查德·佩托爵士（生于1943年）的工作至关重要。佩托将创新的方法贡献与大规模实证研究相结合，这些研究通常基于全球合作，特别关注吸烟与健康、乳腺癌治疗以及降低胆固醇的干预措施。他的工作既产生了又唤起了令人印象深刻的证据基础，以改善临床和公共卫生实践。根据荷兰皇家艺术与科学学院一个评选委员会的建议，他于2008年10月2日被授予A.H. 喜力医学奖。
