Pakfetrat Maryam, Malekmakan Leila, Roozbeh Jamshid, Haghpanah Sezaneh
Nephro-Urology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Magnes Res. 2008 Sep;21(3):167-70.
Hypomagnesaemia has been reported among patients undergoing hemodialysis (HD). Recently, a possible correlation between serum magnesium (Mg) and C-reactive protein (CRP) has been stressed. This correlation has been attributed to cytokine production and oxidative stress processes. In this study we aimed to determine the relationship between serum Mg and hs-CRP levels in patients undergoing HD. This is a cross sectional study based on data collected from 58 HD patients in the Sahraee Center of Shiraz, Iran in 2007. Data were analyzed by SPSS.15, using Mann-Whitney test, Pair t-test, and Pearson's correlation coefficient. A p value of less than 0.05 was considered significant. The present study included 58 HD patients (33 M and 25 F). The mean age of our patients was 51 +/- 17.5 years old. At the start of HD, 39% of our patients had hypomagnesaemia and 60% had high hs-CRP, and 31% had both. There was a significant negative correlation between serum Mg and serum hs-CRP (p < 0.04). Also, in those who had hypomagnesaemia, hs-CRP was higher (p < 0.02). The results of this research support our hypothesis that hypomagnesaemia in pre-dialysis patients is a risk factor for sub-clinical inflammation due to hs-CRP elevation, although further studies are clearly required.
血液透析（HD）患者中曾有低镁血症的报道。最近，血清镁（Mg）与C反应蛋白（CRP）之间的可能关联受到了关注。这种关联被认为与细胞因子产生及氧化应激过程有关。在本研究中，我们旨在确定HD患者血清镁与高敏CRP（hs-CRP）水平之间的关系。这是一项横断面研究，基于2007年从伊朗设拉子Sahraee中心的58例HD患者收集的数据。数据采用SPSS.15进行分析，使用Mann-Whitney检验、配对t检验和Pearson相关系数。p值小于0.05被视为具有统计学意义。本研究纳入了58例HD患者（33例男性和25例女性）。患者的平均年龄为51±17.5岁。在HD开始时，39%的患者有低镁血症，60%的患者hs-CRP升高，31%的患者两者都有。血清镁与血清hs-CRP之间存在显著负相关（p<0.04）。此外，在有低镁血症的患者中，hs-CRP更高（p<0.02）。本研究结果支持我们的假设，即透析前患者的低镁血症是hs-CRP升高导致亚临床炎症的危险因素，尽管显然还需要进一步研究。
