慢性肾脏病患者的血清镁水平：与炎症状态有关吗？
Serum Magnesium Levels in Patients with Chronic Kidney Disease: Is There a Relationship with Inflammation Status?
机构信息
Graduate Program in Nutrition Sciences, Fluminense Federal University (UFF), Niterói, RJ, Brazil.
Graduate Program in Biological Sciences - Physiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro (RJ), Brazil.
出版信息
Biol Trace Elem Res. 2024 May;202(5):1983-1990. doi: 10.1007/s12011-023-03829-3. Epub 2023 Sep 2.
BACKGROUND
Magnesium (Mg) is a fundamental mineral that maintains cellular function, and low levels may be linked to inflammation in patients with chronic kidney disease (CKD). This cross-sectional study evaluated the correlation between serum Mg levels and the inflammatory status in patients undergoing dialysis.
METHODS
Two hundred patients with CKD [150 undergoing hemodialysis (HD), 50 (18) years; BMI 24 (4.8) kg/m²; and 50 patients on peritoneal dialysis (PD), 54 (17.7) years; BMI, 27.5 (7.3) kg/m²] were included. Serum Mg levels were evaluated using a colourimetric test and commercial kit. Inflammatory markers were assessed by ELISA and multiplex bead-based assay. Lipid peroxidation was evaluated using thiobarbituric acid-reactive substances.
RESULTS
The median serum Mg levels were 2.3 (0.5) mg/dL, and 21% of patients presented Mg deficiency (< 2.07 mg/dL or 0.85 mmol/L). We found no difference in Mg serum levels between the two groups. A significant negative correlation was observed between serum Mg levels and plasma hs-CRP (r =-0.17, p = 0.01), IL-8 (r =-0.35, p = 0.01), and MCP-1 (r =-0.31, p = 0.03) levels.
CONCLUSION
Mg serum levels were negatively correlated with inflammatory status in patients with CKD on dialysis.
背景
镁（Mg）是一种维持细胞功能的基本矿物质，其水平降低可能与慢性肾脏病（CKD）患者的炎症有关。本横断面研究评估了透析患者血清 Mg 水平与炎症状态之间的相关性。
方法
纳入 200 例 CKD 患者[150 例血液透析（HD）患者，年龄 50（18）岁；BMI 24（4.8）kg/m²；50 例腹膜透析（PD）患者，年龄 54（17.7）岁；BMI 27.5（7.3）kg/m²]。采用比色法和商业试剂盒评估血清 Mg 水平。通过酶联免疫吸附法和多重珠粒基于测定法评估炎症标志物。通过硫代巴比妥酸反应性物质评估脂质过氧化。
结果
血清 Mg 中位数水平为 2.3（0.5）mg/dL，21%的患者存在 Mg 缺乏症（<2.07mg/dL 或 0.85mmol/L）。两组间血清 Mg 水平无差异。血清 Mg 水平与血浆 hs-CRP（r=-0.17，p=0.01）、IL-8（r=-0.35，p=0.01）和 MCP-1（r=-0.31，p=0.03）水平呈显著负相关。
结论
透析 CKD 患者血清 Mg 水平与炎症状态呈负相关。
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