Keinan-Boker Lital, Lerner-Geva Liat, Kaufman Bella, Meirow Dror
Israel Center for Disease Control, Ministry of Health, Sheba Medical Center of Health Policy Research, Tel Hashomer, Israel.
Isr Med Assoc J. 2008 Oct;10(10):722-7.
The frequency of pregnancy-associated breast cancer, a rare but serious occurrence, may increase in light of the secular trends for lower parity in general and for older age at first full-term delivery in particular Data on PABC in individuals who are at high risk for breast cancer are limited. A computerized search of Pubmed showed that the reported incidence of PABC is 1:3000 pregnancies; it is often diagnosed at an advanced stage and its prognosis is inferior compared to non-PABC Carriers of mutations in the genes BRCA1/2 may present a specific high risk group for PABC especially at younger ages. Women treated with fertility treatment drugs may be at a higher risk for PABC as well.
妊娠相关乳腺癌虽罕见但严重，鉴于总体生育次数下降尤其是首次足月分娩年龄增大的长期趋势，其发病率可能会上升。乳腺癌高危个体中妊娠相关乳腺癌的数据有限。对PubMed进行计算机检索显示，报道的妊娠相关乳腺癌发病率为每3000次妊娠中有1例；其常被诊断为晚期，与非妊娠相关乳腺癌相比，其预后较差。BRCA1/2基因突变携带者可能是妊娠相关乳腺癌的特定高危人群，尤其是在较年轻的时候。接受生育治疗药物治疗的女性患妊娠相关乳腺癌的风险也可能更高。
