Johnson A, Löfström J B
Department of Anaesthesiology, University Hospital, Linköping University, Sweden.
Reg Anesth. 1991 Jan-Feb;16(1):7-12.
Local anesthetics (lidocaine, mepivacaine or bupivacaine) were given as an intravenous infusion to 18 volunteers to study the influence of these drugs on resting ventilation (breathing air) and stimulated ventilation (hypercarbia- or hypoxemia-induced). Control measurements were made of resting ventilation and stimulated ventilation prior to the infusion. The ventilatory measurements were repeated during the latter half of the infusion, when plasma concentrations of these agents were considered to be near steady-state levels (mean plasma levels of lidocaine, mepivacaine and bupivacaine, 3.1 micrograms/ml, 2.7 micrograms/ml and 1.5 micrograms/ml, respectively) and within a range normally achieved clinically. None of the drugs tested affected resting ventilation or ventilation stimulated by hypercarbia. The drugs tested exerted a slight stimulatory effect on ventilation during hypoxemia.
将局部麻醉药（利多卡因、甲哌卡因或布比卡因）静脉输注给18名志愿者，以研究这些药物对静息通气（呼吸空气时）和刺激通气（高碳酸血症或低氧血症诱导）的影响。在输注前对静息通气和刺激通气进行对照测量。在输注后半段重复进行通气测量，此时这些药物的血浆浓度被认为接近稳态水平（利多卡因、甲哌卡因和布比卡因的平均血浆水平分别为3.1微克/毫升、2.7微克/毫升和1.5微克/毫升），且处于临床通常达到的范围内。所测试的药物均未影响静息通气或高碳酸血症刺激的通气。所测试的药物在低氧血症期间对通气有轻微的刺激作用。
