Nakai T, Uchihashi Y, Satoh T
Department of Anesthesiology, National Defense Medical College, Tokorozawa.
Masui. 1995 Oct;44(10):1356-61.
The effects of local anesthetics on learning were assessed in mice through one trial step-through passive avoidance performance. Lidocaine HCl (10, 20 or 40 mg.kg-1), mepivacaine HCl (15, 30 or 60 mg.kg-1) or bupivacaine HCl (2.5, 5 or 10 mg.kg-1) were injected subcutaneously 10 min before acquisition training. Lidocaine, but not mepivacaine and bupivacaine, reduced the latency in the retention trial conducted 24hr after the training in a dose-dependent manner. However, lidocaine did not alter the latency when it was given 10 min before the retention trial. These results suggest that lidocaine impairs acquisition, but not retention or retrieval phase in the memory process.
通过单次步入式被动回避行为测试评估了局部麻醉药对小鼠学习能力的影响。在获得性训练前10分钟，皮下注射盐酸利多卡因（10、20或40mg.kg-1）、盐酸甲哌卡因（15、30或60mg.kg-1）或盐酸布比卡因（2.5、5或10mg.kg-1）。利多卡因而非甲哌卡因和布比卡因，以剂量依赖的方式缩短了训练后24小时进行的记忆测试中的潜伏期。然而，在记忆测试前10分钟给予利多卡因时，其并未改变潜伏期。这些结果表明，利多卡因损害记忆过程中的获得阶段，但不影响保持或提取阶段。
