Toyoshima Chikashi
Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-0032, Japan.
Biochim Biophys Acta. 2009 Jun;1793(6):941-6. doi: 10.1016/j.bbamcr.2008.10.008. Epub 2008 Oct 29.
Ca2+-ATPase of muscle sarcoplasmic reticulum is an ATP-powered Ca2+-pump that establishes a >10,000 fold concentration gradient across the membrane. Its crystal structures have been determined for 9 different states that cover nearly the entire reaction cycle. Presented here is a brief structural account of the ion pumping process, with emphasis on why the structure has to be so.
肌肉肌浆网的Ca2+ -ATP酶是一种由ATP驱动的Ca2+泵，它能在膜两侧建立起超过10000倍的浓度梯度。已经确定了其9种不同状态的晶体结构，这些状态几乎涵盖了整个反应周期。本文简要介绍了离子泵浦过程的结构，重点阐述了结构为何必须如此。
