Berridge Michael J
The Babraham Institute, Babraham, Cambridge CB2 4AT, UK.
Biochim Biophys Acta. 2009 Jun;1793(6):933-40. doi: 10.1016/j.bbamcr.2008.10.005. Epub 2008 Oct 29.
Studies on control of fluid secretion by an insect salivary gland led to the discovery of inositol trisphosphate (IP3) and its role in calcium signalling. Many cell stimuli act on receptors that are coupled to phospholipase C that hydrolyses phosphatidylinosol 4,5-bisphosphate (PIP2) to release IP3 to the cytosol. IP3 receptors located on the endoplasmic reticulum respond to this elevation of IP3 by releasing Ca2+, which is often organized into characteristic spatial (elementary events and waves) and temporal (Ca2+ oscillations) patterns. This IP3/Ca2+ pathway is a remarkably versatile signalling system that has been adapted to control processes as diverse as fertilization, proliferation, contraction, cell metabolism, vesicle and fluid secretion and information processing in neuronal cells.
对昆虫唾液腺液体分泌控制的研究促成了肌醇三磷酸（IP3）的发现及其在钙信号传导中的作用。许多细胞刺激作用于与磷脂酶C偶联的受体，磷脂酶C水解磷脂酰肌醇4,5-二磷酸（PIP2）以释放IP3到细胞质中。位于内质网上的IP3受体通过释放Ca2+对IP3的这种升高做出反应，Ca2+通常被组织成特征性的空间（基本事件和波）和时间（Ca2+振荡）模式。这种IP3/Ca2+途径是一个非常通用的信号系统，已被用于控制受精、增殖、收缩、细胞代谢、囊泡和液体分泌以及神经元细胞中的信息处理等多种过程。
