Animal Health Research Institute, Council of Agriculture, 376 Chung-Cheng Road, Tamsui, Taipei 251, Taiwan.
Vet J. 2010 Feb;183(2):184-90. doi: 10.1016/j.tvjl.2008.10.001. Epub 2008 Nov 17.
Canine distemper (CD) is a highly contagious disease with a worldwide distribution. Genetic diversity in genes encoding the haemagglutinin (H) and fusion (F) virus envelope proteins have been implicated in the increasing incidence of CD. Unlike the H gene, little is known about the genetic variability of the F gene in this virus. In the present study sequence analysis of the complete coding region of the F protein from CD virus isolates from Taiwan were carried out. Phylogenetic analysis demonstrated that the majority of isolates were similar to those found in neighbouring China and Japan, but were genetically distinct from vaccine strains. Remarkable variations were found scattered throughout the pre-peptide region (residues 1-135). The sequence identity of this region between locally sourced strains and between these strains and vaccine strains was 89% and 64 to 67%, respectively. Analysis suggested a novel strain of distant genetic lineage was present in dogs in the geographically isolated city of Hualien.
犬瘟热（CD）是一种具有全球分布的高度传染性疾病。编码血凝素（H）和融合（F）病毒包膜蛋白的基因的遗传多样性与 CD 的发病率增加有关。与 H 基因不同，关于该病毒 F 基因的遗传变异性知之甚少。在本研究中，对来自台湾的 CD 病毒分离株的 F 蛋白完整编码区进行了序列分析。系统进化分析表明，大多数分离株与中国和日本的分离株相似，但与疫苗株在遗传上有明显区别。在前肽区域（残基 1-135）中发现了显著的变异。该区域中本地来源的菌株之间以及这些菌株与疫苗株之间的序列同一性分别为 89%和 64 至 67%。分析表明，在地理上孤立的花莲市的犬中存在一种遗传谱系较远的新型毒株。
