Khakoo Aarif Y, Sidman Richard L, Pasqualini Renata, Arap Wadih
The University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.
Cancer Res. 2008 Nov 15;68(22):9112-5. doi: 10.1158/0008-5472.CAN-08-0851.
Several lines of evidence suggest that hypertension and angiogenesis may be related phenomena but a functional link remains elusive. Here, we propose that the renin-angiotensin system (RAS), in addition to its central role in arterial hypertension, also regulates blood vessel formation during normal development and cancer. This mechanistic hypothesis is based on reports of biochemical, genetic, clinical, and epidemiologic data reviewed herein. Species differences between the RAS of rodents and humans likely account for why such a fundamental role in angiogenesis went unrecognized for so long. If proven correct, this hypothesis carries many implications for the medical practices of cardiology, oncology, and neonatology.
多条证据表明高血压和血管生成可能是相关现象，但功能联系仍不明确。在此，我们提出肾素-血管紧张素系统（RAS），除了在动脉高血压中起核心作用外，在正常发育和癌症过程中也调节血管形成。这一机制假说基于本文所综述的生化、遗传、临床和流行病学数据报告。啮齿动物和人类RAS之间的物种差异可能解释了为何血管生成中的这一基本作用长期未被认识。如果这一假说被证明是正确的，将对心脏病学、肿瘤学和新生儿学的医疗实践产生诸多影响。
