Reif S, Tano M, Oliverio R, Young C, Rossi T
Division of Gastroenterology, Children's Hospital of Buffalo, New York.
JPEN J Parenter Enteral Nutr. 1991 Jan-Feb;15(1):102-4. doi: 10.1177/0148607191015001102.
Prolonged use of total parenteral nutrition (TPN) may be associated with hepatic complications, primarily steatosis and cholestasis. A case is reported of an 18-year-old woman with chronic idiopathic intestinal pseudo-obstruction syndrome who was on prolonged home parenteral nutrition without lipid supplementation and developed steatosis. This finding was reversed by addition of lipid emulsion, at a dose of 0.5 g/kg/day, to the parenteral nutrition solution. The lack of lipid supplementation as a possible cause of steatosis, as well as other mechanisms of liver steatosis associated with TPN, are discussed.
长期使用全胃肠外营养（TPN）可能与肝脏并发症相关，主要是脂肪变性和胆汁淤积。本文报道了1例18岁患有慢性特发性肠道假性梗阻综合征的女性患者，该患者长期在家接受胃肠外营养且未补充脂质，进而出现了脂肪变性。通过在胃肠外营养溶液中添加剂量为0.5 g/kg/天的脂质乳剂，这一发现得到了逆转。文中讨论了未补充脂质作为脂肪变性可能原因的情况，以及与TPN相关的肝脏脂肪变性的其他机制。
