主动脉弓上动脉：3.0-T高空间分辨率磁共振血管造影中对比剂剂量减少——可行性研究
Supraaortic arteries: contrast material dose reduction at 3.0-T high-spatial-resolution MR angiography--feasibility study.
作者信息
Tomasian Anderanik, Salamon Noriko, Lohan Derek G, Jalili Mehdi, Villablanca J Pablo, Finn J Paul
机构信息
Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Suite 3371, Peter V. Ueberroth Building, 10945 Le Conte Ave, Los Angeles, CA 90095-7206, USA.
出版信息
Radiology. 2008 Dec;249(3):980-90. doi: 10.1148/radiol.2493080209.
PURPOSE
To evaluate and compare the diagnostic image quality resulting from three contrast agent dose regimens for 3.0-T high-spatial-resolution three-dimensional magnetic resonance (MR) angiography of the supraaortic arteries.
MATERIALS AND METHODS
Institutional review board approval was obtained; informed consent was waived for this HIPAA-compliant study. One hundred twenty consecutive patients who underwent 3.0-T three-dimensional high-spatial-resolution contrast material-enhanced MR angiography of the supraaortic arteries with an identical acquisition protocol were assigned to either the high-dose (0.154 mmol per kilogram of body weight), intermediate-dose (0.097 mmol/kg), or low-dose (0.047 mmol/kg) group. Two readers evaluated resulting images for arterial definition, venous contamination, and arterial stenosis. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were evaluated at six consistent sites. Statistical analysis was performed with the Kruskal-Wallis, Wilcoxon signed rank, and analysis of variance tests and the kappa coefficient.
RESULTS
Readers 1 and 2 scored vascular definition as excellent or sufficient for diagnosis in 1311 of 1360 segments and in 1313 of 1360 segments in the high-dose group (kappa = 0.73), in 1321 of 1354 and in 1319 of 1354 segments in the intermediate-dose group (kappa = 0.77), and in 1322 of 1350 and in 1320 of 1350 segments in the low-dose group (kappa= 0.66), respectively. Arterial occlusive disease was detected by reader 1 in 52, 27, and 98 segments in the high-, intermediate-, and low-dose groups, respectively. Arterial occlusive disease was detected by reader 2 in 48, 25, and 100 segments in high-, intermediate-, and low-dose groups, respectively. No significant difference existed among the three groups regarding arterial definition scores (reader 1, P = .21; reader 2, P = .25) and venous contamination scores (reader 1, P = .38; reader 2, P = .35). SNRs and CNRs were lower in the low-dose group (P < .01).
CONCLUSION
At 3.0 T, high-spatial-resolution MR angiography of the supraaortic arteries can be performed with contrast agent doses as low as 0.047 mmol/kg, without compromising image quality, acquisition speed, or spatial resolution.
SUPPLEMENTAL MATERIAL
目的
评估并比较三种造影剂剂量方案用于3.0-T高空间分辨率三维磁共振（MR）血管造影术对主动脉弓上动脉成像的诊断图像质量。
材料与方法
本研究获得机构审查委员会批准；对于这项符合健康保险流通与责任法案（HIPAA）的研究，免除了知情同意。120例连续接受3.0-T三维高空间分辨率对比剂增强MR血管造影术检查主动脉弓上动脉的患者，采用相同的采集方案，被分配至高剂量组（0.154 mmol/千克体重）、中剂量组（0.097 mmol/kg）或低剂量组（0.047 mmol/kg）。两名阅片者对所得图像进行动脉清晰度、静脉污染和动脉狭窄评估。在六个一致的部位评估信噪比（SNR）和对比噪声比（CNR）。采用Kruskal-Wallis检验、Wilcoxon符号秩检验、方差分析和kappa系数进行统计分析。
结果
阅片者1和阅片者2对高剂量组1360个节段中的1311个节段和1360个节段中的1313个节段的血管清晰度评分诊断为优秀或足以诊断（kappa = 0.73），中剂量组1354个节段中的1321个节段和1354个节段中的1319个节段（kappa = 0.77），低剂量组1350个节段中的1322个节段和1350个节段中的1320个节段（kappa = 0.66）。阅片者1在高、中、低剂量组分别检测到52、27和98个节段的动脉闭塞性疾病。阅片者2在高、中、低剂量组分别检测到48、25和100个节段的动脉闭塞性疾病。三组在动脉清晰度评分（阅片者1，P = 0.21；阅片者2，P = 0.25）和静脉污染评分（阅片者1，P = 0.38；阅片者2，P = 0.35）方面无显著差异。低剂量组的SNR和CNR较低（P < 0.01）。
结论
在3.0 T时，主动脉弓上动脉的高空间分辨率MR血管造影术可使用低至0.047 mmol/kg的造影剂剂量进行，而不影响图像质量、采集速度或空间分辨率。
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