Tomasian Anderanik, Salamon Noriko, Lohan Derek G, Jalili Mehdi, Villablanca J Pablo, Finn J Paul
Department of Radiological Sciences, David Geffen School of Medicine, University of California at Los Angeles, Suite 3371, Peter V. Ueberroth Building, 10945 Le Conte Ave, Los Angeles, CA 90095-7206, USA.
Radiology. 2008 Dec;249(3):980-90. doi: 10.1148/radiol.2493080209.
To evaluate and compare the diagnostic image quality resulting from three contrast agent dose regimens for 3.0-T high-spatial-resolution three-dimensional magnetic resonance (MR) angiography of the supraaortic arteries.
Institutional review board approval was obtained; informed consent was waived for this HIPAA-compliant study. One hundred twenty consecutive patients who underwent 3.0-T three-dimensional high-spatial-resolution contrast material-enhanced MR angiography of the supraaortic arteries with an identical acquisition protocol were assigned to either the high-dose (0.154 mmol per kilogram of body weight), intermediate-dose (0.097 mmol/kg), or low-dose (0.047 mmol/kg) group. Two readers evaluated resulting images for arterial definition, venous contamination, and arterial stenosis. Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were evaluated at six consistent sites. Statistical analysis was performed with the Kruskal-Wallis, Wilcoxon signed rank, and analysis of variance tests and the kappa coefficient.
Readers 1 and 2 scored vascular definition as excellent or sufficient for diagnosis in 1311 of 1360 segments and in 1313 of 1360 segments in the high-dose group (kappa = 0.73), in 1321 of 1354 and in 1319 of 1354 segments in the intermediate-dose group (kappa = 0.77), and in 1322 of 1350 and in 1320 of 1350 segments in the low-dose group (kappa= 0.66), respectively. Arterial occlusive disease was detected by reader 1 in 52, 27, and 98 segments in the high-, intermediate-, and low-dose groups, respectively. Arterial occlusive disease was detected by reader 2 in 48, 25, and 100 segments in high-, intermediate-, and low-dose groups, respectively. No significant difference existed among the three groups regarding arterial definition scores (reader 1, P = .21; reader 2, P = .25) and venous contamination scores (reader 1, P = .38; reader 2, P = .35). SNRs and CNRs were lower in the low-dose group (P < .01).
At 3.0 T, high-spatial-resolution MR angiography of the supraaortic arteries can be performed with contrast agent doses as low as 0.047 mmol/kg, without compromising image quality, acquisition speed, or spatial resolution.
评估并比较三种造影剂剂量方案用于3.0-T高空间分辨率三维磁共振（MR）血管造影术对主动脉弓上动脉成像的诊断图像质量。
本研究获得机构审查委员会批准；对于这项符合健康保险流通与责任法案（HIPAA）的研究，免除了知情同意。120例连续接受3.0-T三维高空间分辨率对比剂增强MR血管造影术检查主动脉弓上动脉的患者，采用相同的采集方案，被分配至高剂量组（0.154 mmol/千克体重）、中剂量组（0.097 mmol/kg）或低剂量组（0.047 mmol/kg）。两名阅片者对所得图像进行动脉清晰度、静脉污染和动脉狭窄评估。在六个一致的部位评估信噪比（SNR）和对比噪声比（CNR）。采用Kruskal-Wallis检验、Wilcoxon符号秩检验、方差分析和kappa系数进行统计分析。
阅片者1和阅片者2对高剂量组1360个节段中的1311个节段和1360个节段中的1313个节段的血管清晰度评分诊断为优秀或足以诊断（kappa = 0.73），中剂量组1354个节段中的1321个节段和1354个节段中的1319个节段（kappa = 0.77），低剂量组1350个节段中的1322个节段和1350个节段中的1320个节段（kappa = 0.66）。阅片者1在高、中、低剂量组分别检测到52、27和98个节段的动脉闭塞性疾病。阅片者2在高、中、低剂量组分别检测到48、25和100个节段的动脉闭塞性疾病。三组在动脉清晰度评分（阅片者1，P = 0.21；阅片者2，P = 0.25）和静脉污染评分（阅片者1，P = 0.38；阅片者2，P = 0.35）方面无显著差异。低剂量组的SNR和CNR较低（P < 0.01）。
在3.0 T时，主动脉弓上动脉的高空间分辨率MR血管造影术可使用低至0.047 mmol/kg的造影剂剂量进行，而不影响图像质量、采集速度或空间分辨率。
