Fenchel Michael, Doering Joerg, Seeger Achim, Kramer Ulrich, Rittig Kilian, Klumpp Bernhard, Claussen Claus D, Miller Stephan
Department of Diagnostic Radiology, Eberhard-Karls-University Tuebingen, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.
Radiology. 2009 Jan;250(1):254-63. doi: 10.1148/radiol.2501080494. Epub 2008 Nov 10.
The study was approved by the local ethics committee, and informed consent was provided by all participants prior to the examination. The aim of the study was to assess the feasibility of whole-body three-dimensional (3D) contrast material-enhanced magnetic resonance (MR) angiography with parallel imaging in the phase- and section-encoding directions (ie, integrated parallel acquisition technique [iPAT(2); Siemens, Erlangen, Germany]) for all anatomic imaging stations in combination with a single injection of contrast material. Whole-body contrast-enhanced MR angiography was performed in 23 patients at 3.0 T. Images were evaluated by two independent observers for quality on a four-point scale (where a score of 1 indicated poor image quality and a score of 4, excellent image quality); signal-to-noise ratios (SNRs) and contrast-to-noise ratios (CNRs) were calculated for representative vessel regions in each station. Mean image quality scores were 3.13 +/- 1.15 (standard deviation) and 3.17 +/- 1.14 for observers 1 and 2, respectively (kappa = 0.81). Signal intensity measurements revealed mean SNR values between 36.2 +/- 8.0 and 56.2 +/- 17.7 and mean CNR values between 29.0 +/- 7.4 and 48.2 +/- 15.7. The data suggest that contrast-enhanced MR angiography with iPAT(2) is feasible for whole-body applications and allows acquisition of 3D data sets with adequate spatial resolution within short measurement times, facilitating a single injection of contrast material.
本研究经当地伦理委员会批准,所有参与者在检查前均提供了知情同意书。本研究的目的是评估在相位编码和层面编码方向上采用并行成像技术(即集成并行采集技术[iPAT(2);西门子公司,德国埃尔朗根])进行全身三维(3D)对比剂增强磁共振(MR)血管造影结合单次注射对比剂用于所有解剖成像部位的可行性。对23例患者在3.0 T磁场强度下进行全身对比增强MR血管造影。由两名独立观察者按照四分制对图像质量进行评估(1分表示图像质量差,4分表示图像质量优秀);计算每个部位代表性血管区域的信噪比(SNR)和对比噪声比(CNR)。观察者1和观察者2的平均图像质量评分分别为3.13±1.15(标准差)和3.17±1.14(kappa = 0.81)。信号强度测量结果显示,平均SNR值在36.2±8.0至56.2±17.7之间,平均CNR值在29.0±7.4至48.2±15.7之间。数据表明,采用iPAT(2)的对比增强MR血管造影用于全身检查是可行的,能够在短测量时间内获取具有足够空间分辨率的3D数据集,便于单次注射对比剂。