Mahajan Sanjay K, Rolain Jean-Marc, Sankhyan Naveen, Kaushal Ram Krishan, Raoult Didier
Department of Pediatrics, IG Medical College, Shimla, HP, India.
Indian J Pediatr. 2008 Sep;75(9):947-9. doi: 10.1007/s12098-008-0198-z. Epub 2008 Nov 15.
To retrospectively confirm the suspected rickettsial disease (Scrub typhus) using a gold standard diagnostic test i.e. microimmunofluorescence in pediatric patients with acute febrile illness of unknown etiology. Two serological tests, Weil-Felix and Microimmunofluorescence were used to confirm infection. All five children had fever, vomiting and generalized lymphadenopathy, but none had eschar or rash. One was cured with doxycycline, remaining four patients treated with azithromycin and one died despite treatment. Scrub typhus is a cause of fever of unknown origin in Himalayan region of India and azithromycin is an effective alternative to doxycycline in treating this disease.
使用金标准诊断测试即微量免疫荧光法，对病因不明的急性发热性疾病患儿进行回顾性确诊疑似立克次体病（恙虫病）。采用两种血清学检测方法，即外斐反应和微量免疫荧光法来确诊感染。所有5名儿童均有发热、呕吐和全身淋巴结肿大，但均无焦痂或皮疹。1名儿童用多西环素治愈，其余4名患者用阿奇霉素治疗，1名患者尽管接受了治疗仍死亡。恙虫病是印度喜马拉雅地区不明原因发热的病因之一，阿奇霉素是治疗该病的多西环素的有效替代药物。
