Brüne M
Psychiatrie, Psychotherapie, Psychosomatik und Präventivmedizin, LWL Universitätsklinik Bochum, Ruhr-Universität Bochum, Alexandrinenstrasse 1, 44791, Bochum, Deutschland.
Nervenarzt. 2009 Mar;80(3):252-62. doi: 10.1007/s00115-008-2591-2.
The multifaceted question of whether psychiatric disorders are specific to human beings can not simply be answered "yes" or "no". Tackling the question can nevertheless be important because many symptoms characteristic of human psychiatric disorders can be found in behaviourally abnormal animals. From this perspective therefore the answer must be "no". Research into the environmental causes of such symptoms, for example in our closest extant relatives, the nonhuman primates, can potentially contribute to the prevention of human psychiatric disorders. Moreover, research into animal models of psychiatric disorders has made great progress in terms of both aetiology and (pharmaco-) therapeutic options. Even though the applicability of findings to human disorders is contested, it is hardly ever questioned. In any event, is there anything specific to humans that animal models can not express and that render studies of human experience and behaviour indispensible? The answer can only be "yes" because human experience and behaviour have evolved in a species-typical way. Accordingly, future multidisciplinary research should be thoroughly grounded in the natural sciences, preferably adopting a structure after Tinbergen's four "W" questions on ontogeny, mechanism, phylogeny, and adaptive value.
精神疾病是否为人类所特有这一涉及多方面的问题,不能简单地用“是”或“否”来回答。然而,探讨这个问题很重要,因为在行为异常的动物身上能发现许多人类精神疾病特有的症状。因此,从这个角度来看,答案必然是“否”。对这类症状的环境成因进行研究,比如在我们现存的近亲——非人灵长类动物身上进行研究,可能有助于预防人类精神疾病。此外,在精神疾病动物模型的病因学和(药物)治疗选择方面,研究都取得了很大进展。尽管研究结果对人类疾病的适用性存在争议,但这几乎从未受到质疑。无论如何,是否存在动物模型无法表现的、使人类经验和行为研究不可或缺的人类特有因素呢?答案只能是“是”,因为人类经验和行为是以物种特有的方式进化而来的。因此,未来的多学科研究应完全基于自然科学,最好采用廷伯根关于个体发生、机制、系统发生和适应性价值的四个“W”问题的结构。