FTSJ1基因变异影响中国汉族人群年轻男性的认知能力。
Genetic variations in FTSJ1 influence cognitive ability in young males in the Chinese Han population.
作者信息
Gong Pingyuan, Li Jing, Dai Ling, Zhang Kejin, Zheng Zijian, Gao Xiaocai, Zhang Fuchang
机构信息
School of Life Science, Institute of Population and Health, Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, China
出版信息
J Neurogenet. 2008;22(4):277-87. doi: 10.1080/01677060802337299.
Human cognitive ability is a trait that is known to be significantly influenced by genetic factors. Previous linkage data provide evidence suggesting that gene FtsJ homolog 1 (Escherichia coli) is associated with mental retardation. The gene may have a relation to individual differences in cognitive ability because it is most critical for brain development. In the present research, three tag single-nucleotide polymorphism (SNPs) (rs2268954, rs2070991, and rs5905692) in FtsJ homolog 1 (E. coli) are selected and genotyped by the PCR-SSCP method. An analysis of variance is performed to determine the relationship between the SNPs and cognitive ability of the Chinese Han population of youth in Qinba mountain. There are significant correlations between the variance in FtsJ homolog 1 (E. coli) and general cognitive ability, verbal comprehension, and preceptual organization. These findings suggest that genetic variations in FtsJ homolog 1 (E. coli) possibly influence human cognitive ability.
人类认知能力是一种已知受遗传因素显著影响的特质。先前的连锁数据提供了证据，表明FtsJ同源物1（大肠杆菌）基因与智力迟钝有关。该基因可能与认知能力的个体差异有关，因为它对大脑发育最为关键。在本研究中，选择了FtsJ同源物1（大肠杆菌）中的三个标签单核苷酸多态性（SNP）（rs2268954、rs2070991和rs5905692），并通过PCR-SSCP方法进行基因分型。进行方差分析以确定这些SNP与秦巴山区中国汉族青年人群认知能力之间的关系。FtsJ同源物1（大肠杆菌）的变异与一般认知能力、语言理解和知觉组织之间存在显著相关性。这些发现表明，FtsJ同源物1（大肠杆菌）的基因变异可能影响人类认知能力。
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