Jaffe Allan S
Mayo Clinic, Rochester, MN, USA.
Clin Chem Lab Med. 2008;46(11):1485-8. doi: 10.1515/CCLM.2008.296.
All of the recent guidelines now endorse the use of troponin as the biomarker or choice for the diagnosis of acute myocardial infarction (AMI).
Review of the recent guidelines criteria.
Rising and/or falling values of troponin in patients who appear to have ischemic heart disease will result in the diagnosis of AMI. The recent guidelines emphasize the use of the 99th percentile value for troponin and suggest it should be measurable with a high level of precision. They also suggest how to operationalize determining a significant change for patients who appear to have recurrent infarction and classify AMI into five subtypes.
Understanding these criteria will be important to a consistent approach to the diagnosis of AMI in the future.
所有近期指南均认可将肌钙蛋白作为诊断急性心肌梗死(AMI)的生物标志物或首选指标。
回顾近期指南标准。
在疑似患有缺血性心脏病的患者中,肌钙蛋白值的升高和/或降低将导致AMI的诊断。近期指南强调使用肌钙蛋白的第99百分位数,并建议其应具有高精度的可测量性。它们还提出了如何对疑似复发性梗死患者确定显著变化进行操作,并将AMI分为五个亚型。
了解这些标准对于未来采用一致的方法诊断AMI至关重要。