伊马替尼治疗肾源性系统性纤维化
Imatinib in the treatment of nephrogenic systemic fibrosis.
作者信息
Chandran Sindhu, Petersen Jeffrey, Jacobs Charlotte, Fiorentino David, Doeden Katherine, Lafayette Richard A
机构信息
Division of Nephrology, Stanford University, Stanford, CA 94305-5114, USA.
出版信息
Am J Kidney Dis. 2009 Jan;53(1):129-32. doi: 10.1053/j.ajkd.2008.08.029. Epub 2008 Nov 13.
Nephrogenic systemic fibrosis is a disabling progressive condition that is being reported with increased frequency in patients with kidney disease. Treatment is extremely limited and largely supportive. We report a case of severe nephrogenic systemic fibrosis in a dialysis patient exposed to multiple doses of gadolinium who improved clinically and histologically with treatment with imatinib.
肾源性系统性纤维化是一种致残性进行性疾病，在肾病患者中的报告频率日益增加。治疗方法极为有限，主要是支持性治疗。我们报告了一例接受多次钆剂注射的透析患者发生严重肾源性系统性纤维化的病例，该患者经伊马替尼治疗后临床和组织学表现均有改善。
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