WF-2421, a new aldose reductase inhibitor produced from a fungus, Humicola grisea.
作者信息
Nishikawa M, Tsurumi Y, Murai H, Yoshida K, Okamoto M, Takase S, Tanaka H, Hirota H, Hashimoto M, Kohsaka M
机构信息
Exploratory Research Laboratoires, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
出版信息
J Antibiot (Tokyo). 1991 Feb;44(2):130-5. doi: 10.7164/antibiotics.44.130.
PMID:1901310
Abstract
WF-2421 is a novel aldose reductase inhibitor produced by Humicola grisea. WF-2421 was purified from the culture filtrate by successive ion exchange chromatography and the chemical structure was assigned to be alpha-formamido-5'-(2-formamido-1-hydroxyethyl)- beta,2',6-trihydroxy-3-biphenylpropanoic acid (1) on the basis of spectroscopic evidence. The IC50 value of WF-2421 was 3 x 10(-8) M against partially purified aldose reductase of rabbit lens.
摘要
Zotero 插件