YUA001，一种从嗜碱棒状杆菌YUA25中分离出的新型醛糖还原酶抑制剂。I. 分类学、发酵、分离及特性

YUA001, a novel aldose reductase inhibitor isolated from alkalophilic Corynebacterium sp. YUA25. I. Taxonomy, fermentation, isolation and characterization.

作者信息

Bahn Y, Park J, Bai D, Takase S, Yu J

机构信息

Department of Food and Biotechnology, and Bioproducts Research Center, Yonsei University, Seoul, Korea.

出版信息

J Antibiot (Tokyo). 1998 Oct;51(10):902-7. doi: 10.7164/antibiotics.51.902.

DOI:10.7164/antibiotics.51.902

PMID:9917002

Abstract

YUA001 is a novel aldose reductase inhibitor produced from alkalophilic Corynebacterium sp. YUA25 isolated from soil. YUA001 was purified from the supernatant of culture broth by successive silica gel column chromatography, Sephadex LH20-100 gel column chromatography, and HPLC. From instrumental analysis, molecular formula of YUA001 is C13H19NO2 and its molecular weight is 221. It exhibits potent aldose reductase inhibition activity and has no antimicrobial activity against some gram-positive or gram-negative bacteria, fungi and yeast.

摘要

YUA001是一种新型醛糖还原酶抑制剂，由从土壤中分离出的嗜碱棒状杆菌YUA25产生。YUA001通过连续硅胶柱色谱、Sephadex LH20 - 100凝胶柱色谱和高效液相色谱从培养液上清液中纯化得到。通过仪器分析，YUA001的分子式为C13H19NO2，分子量为221。它具有很强的醛糖还原酶抑制活性，对一些革兰氏阳性或革兰氏阴性细菌、真菌和酵母没有抗菌活性。