Quincozes-Santos André, Bobermin Larissa Daniele, Kleinkauf-Rocha Juliana, Souza Diogo Onofre, Riesgo Rudimar, Gonçalves Carlos-Alberto, Gottfried Carmem
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Prog Neuropsychopharmacol Biol Psychiatry. 2009 Feb 1;33(1):11-5. doi: 10.1016/j.pnpbp.2008.08.023. Epub 2008 Nov 5.
Risperidone has demonstrated therapeutic advantages over conventional neuroleptics and offers a valuable emerging option for the treatment of social behavior associated with autistic disorder. Considering the putative involvement of astroglial cells in neuropsychiatric disorders, we investigated the effect of risperidone on parameters of astrocyte activity - glutamate uptake, glutamine synthetase (GS) activity and glutathione (GSH) levels. Risperidone was able to induce a significantly increase on glutamate uptake (32%); GS activity (15%); GSH levels (58%). These findings imply the perspectives for further investigations directed on astrocytes from different brain areas. Our present results suggest that risperidone might exert its neuroprotective effects against brain illness at least partially via modulation of astrocyte functions.
利培酮已显示出优于传统抗精神病药物的治疗优势，并为治疗与自闭症谱系障碍相关的社交行为提供了一个有价值的新选择。考虑到星形胶质细胞可能参与神经精神疾病，我们研究了利培酮对星形胶质细胞活性参数——谷氨酸摄取、谷氨酰胺合成酶（GS）活性和谷胱甘肽（GSH）水平的影响。利培酮能够显著增加谷氨酸摄取（32%）、GS活性（15%）和GSH水平（58%）。这些发现为针对不同脑区星形胶质细胞的进一步研究提供了方向。我们目前的结果表明，利培酮可能至少部分通过调节星形胶质细胞功能来发挥其对脑部疾病的神经保护作用。
