Yang Chengfeng, Tan Ying S, Harkema Jack R, Haslam Sandra Z
Department of Physiology, Michigan State University, East Lansing, MI 48824, United States; Breast Cancer and the Environment Research Center, Michigan State University, East Lansing, MI 48824, United States; Center for Integrative Toxicology, Michigan State University, East Lansing, MI 48824, United States.
Department of Physiology, Michigan State University, East Lansing, MI 48824, United States; Breast Cancer and the Environment Research Center, Michigan State University, East Lansing, MI 48824, United States.
Reprod Toxicol. 2009 Jun;27(3-4):299-306. doi: 10.1016/j.reprotox.2008.10.003. Epub 2008 Nov 1.
Perfluorooctanoic acid (PFOA), a common and persistent industrial byproduct detected in human sera, has raised health concerns. PFOA is detrimental to lactational function and postnatal mammary gland development in CD-1 mice after gestational exposure. We have examined the peripubertal period (21 through 50 days of age) as an important window of mammary gland susceptibility to environmental exposures that may affect breast cancer risk later in life. The effects of PFOA (0.1-10mg/kg BW) were examined in Balb/c and C57BL/6 mice. PFOA treatment caused hepatocellular hypertrophy and delayed vaginal opening in both mouse strains. While Balb/c mice exhibited only inhibition of mammary gland and uterine development (5, 10mg/kg), C57BL/6 mice exhibited stimulatory effects in both organs at low dose (5mg/kg) and inhibition at higher dose (10mg/kg). This underscores the need for caution when drawing conclusions about the effects of PFOA and possibly other environmental pollutants on the basis of studies in a single mouse strain.
全氟辛酸（PFOA）是一种在人体血清中被检测到的常见且持久的工业副产品，已引发人们对健康的担忧。孕期接触PFOA会对CD - 1小鼠的泌乳功能和产后乳腺发育产生不利影响。我们将青春期前期（21至50日龄）视为乳腺对可能影响日后患乳腺癌风险的环境暴露敏感的重要窗口期。在Balb/c和C57BL/6小鼠中研究了PFOA（0.1 - 10mg/kg体重）的影响。PFOA处理导致两种小鼠品系均出现肝细胞肥大和阴道开口延迟。虽然Balb/c小鼠仅表现出乳腺和子宫发育受抑制（5、10mg/kg），但C57BL/6小鼠在低剂量（5mg/kg）时两个器官均表现出刺激作用，而在高剂量（10mg/kg）时表现出抑制作用。这凸显了在基于单一小鼠品系的研究得出关于PFOA以及可能其他环境污染物影响的结论时需谨慎的必要性。
