Tucker Deirdre K, Macon Madisa B, Strynar Mark J, Dagnino Sonia, Andersen Erik, Fenton Suzanne E
Curriculum in Toxicology, University of North Carolina at Chapel Hill, School of Medicine, Chapel Hill, NC 27599, United States; National Toxicology Program Laboratory, Division of the NTP, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, United States.
Methods Development and Application Branch, Human Exposure and Atmospheric Sciences Division, National Exposure Research Laboratory, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, United States.
Reprod Toxicol. 2015 Jul;54:26-36. doi: 10.1016/j.reprotox.2014.12.002. Epub 2014 Dec 12.
Perfluorooctanoic acid (PFOA) is a developmental toxicant in mice, with varied strain outcomes depending on dose and period of exposure. The impact of PFOA on female mouse pubertal development at low doses (≤1mg/kg) has yet to be determined. Therefore, female offspring from CD-1 and C57Bl/6 dams exposed to PFOA, creating serum concentrations similar to humans, were examined for pubertal onset, including mammary gland development. Pups demonstrated a shorter PFOA elimination half-life than that reported for adult mice. Prenatal exposure to PFOA caused significant mammary developmental delays in female offspring in both strains. Delays started during puberty and persisted into young adulthood; severity was dose-dependent. Also an evaluation of female serum hormone levels and pubertal timing onset revealed no effects of PFOA compared to controls in either strain. These data suggest that the mammary gland is more sensitive to early low level PFOA exposures compared to other pubertal endpoints, regardless of strain.
全氟辛酸（PFOA）是小鼠体内的一种发育毒性物质，根据剂量和暴露时间的不同，不同品系小鼠会有不同的结果。低剂量（≤1mg/kg）的PFOA对雌性小鼠青春期发育的影响尚未确定。因此，研究人员检测了暴露于PFOA的CD-1和C57Bl/6母鼠所产雌性后代的青春期启动情况，包括乳腺发育，这些后代的血清浓度与人类相似。幼崽的PFOA消除半衰期比成年小鼠报道的要短。产前暴露于PFOA会导致两个品系的雌性后代出现明显的乳腺发育延迟。延迟从青春期开始，并持续到成年早期；严重程度呈剂量依赖性。此外，对雌性血清激素水平和青春期启动时间的评估显示，与对照组相比，PFOA对两个品系均无影响。这些数据表明，无论品系如何，与其他青春期终点相比，乳腺对早期低水平PFOA暴露更为敏感。
