Gunen Hakan, Hacievliyagil Suleyman Savas, Yetkin Ozkan, Gulbas Gazi, Mutlu Levent Cem, Pehlivan Erkan
Department of Pulmonary Medicine, Turgut Ozal Research Center, Inonu University, Malatya, Turkey.
Eur J Intern Med. 2008 Nov;19(7):499-504. doi: 10.1016/j.ejim.2007.06.028. Epub 2008 Mar 14.
Although chronic obstructive pulmonary disease (COPD) is one of the leading causes of mortality and morbidity worldwide, epidemiological data on COPD is very limited. This study was designed to obtain some baseline data on COPD in the Malatya region of Turkey.
Sixty clusters from urban and rural regions were randomly selected. Ten and seven consecutive households were included in the study from each urban and rural cluster, respectively. A validated questionnaire on the epidemiology of COPD was completed for each participant over 18 by a pulmonary physician. Each subject underwent standard spirometric measurement and early bronchodilation testing.
A total of 1160 participants completed the study (93%). Some 6.9% of the participants were found to have COPD (F/M=1/4). While the prevalence of COPD was 18.1% in current smokers over 40 years of age, the prevalence was 4.5% among younger smokers. Some 25.5% of the women and 57.2% of the men were current smokers. Biomass exposure, as a sole reason for COPD, was significantly common among female patients living in rural areas (54.5%). In the development of COPD, the relative risk ratio of cigarette smoke was found to be 3.4 and 3.3 times higher than biomass exposure and occupational exposure, respectively.
Smoking rate and COPD prevalence were found to be unexpectedly high in the region, and biomass exposure is still an important cause of COPD, particularly among females living in rural areas. We think that national policies against smoking and biomass exposure should be implemented immediately.
尽管慢性阻塞性肺疾病(COPD)是全球死亡和发病的主要原因之一,但关于COPD的流行病学数据非常有限。本研究旨在获取土耳其马拉蒂亚地区COPD的一些基线数据。
从城市和农村地区随机选取60个群组。分别从每个城市和农村群组中连续纳入10户和7户家庭参与研究。由肺科医生为每位18岁以上的参与者填写一份经过验证的COPD流行病学调查问卷。每位受试者均接受标准肺量计测量和早期支气管扩张试验。
共有1160名参与者完成了研究(93%)。约6.9%的参与者被发现患有COPD(女性/男性=1/4)。40岁以上的当前吸烟者中COPD患病率为18.1%,而年轻吸烟者中的患病率为4.5%。约25.5%的女性和57.2%的男性为当前吸烟者。作为COPD的唯一原因,生物质暴露在农村地区的女性患者中显著常见(54.5%)。在COPD的发生中,发现香烟烟雾的相对风险比分别比生物质暴露和职业暴露高3.4倍和3.3倍。
该地区的吸烟率和COPD患病率出乎意料地高,生物质暴露仍然是COPD的重要原因,尤其是在农村地区的女性中。我们认为应立即实施针对吸烟和生物质暴露的国家政策。