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单机构2年患者报告的保留神经机器人辅助根治性前列腺切除术后经过验证的性功能结果。

Single institution 2-year patient reported validated sexual function outcomes after nerve sparing robot assisted radical prostatectomy.

作者信息

Rodriguez Esequiel, Finley David S, Skarecky Douglas, Ahlering Thomas E

机构信息

Department of Urology, University of California Irvine, Irvine, California, USA.

出版信息

J Urol. 2009 Jan;181(1):259-63. doi: 10.1016/j.juro.2008.09.015. Epub 2008 Nov 14.

Abstract

PURPOSE

To identify surgeon specific factors for preserving sexual function (and minimize patient related factors) we report 2-year potency outcomes in men 65 years or younger with normal preoperative sexual function undergoing nerve sparing robot assisted laparoscopic radical prostatectomy.

MATERIALS AND METHODS

Between July 2004 and February 2006, 200 consecutive patients underwent robot assisted laparoscopic radical prostatectomy by 1 surgeon. Inclusion criteria were age 65 years or younger with normal baseline 5-item International Index of Erectile Function score of 22 to 25 and complete 2-year followup. Postoperatively potency was defined by a yes to "erections adequate for vaginal penetration" and "satisfactory erections" on prospective self-administered validated questionnaires with or without phosphodiesterase type 5 medications. Men also reported 5-item International Index of Erectile Function scores and erectile fullness of 0% to 10%, 25%, 50%, 75% or 100% compared to before surgery.

RESULTS

A total of 62 patients met the inclusion criteria, and of these 3 were lost to followup and 1 was excluded from study due to receiving hormonal therapy. At 3 months 32.1% reported potency. At 24 months potency was 89.7% (52 of 58) overall, 93.0% (40 of 43) for bilateral and 80.0% (12 of 15) for unilateral nerve sparing. For potent men the mean 5-item International Index of Erectile Function score was 20.4 at 3 months vs 21.3 at 24 months. Mean erectile firmness at 24 months was 91% compared to preoperative baseline, with 34 of 52 (65%) reporting 100% of preoperative fullness. The 5-item International Index of Erectile Function score and fullness at 24 months were equivalent for unilateral nerve sparing and bilateral nerve sparing.

CONCLUSIONS

Overall 90% of men reported return of potency at 24 months, and 46% returned to baseline with normal 5-item International Index of Erectile Function scores and 100% firmness. Remarkably there was no difference in 5-item International Index of Erectile Function scores or fullness between unilateral nerve sparing and bilateral nerve sparing.

摘要

目的

为确定保留性功能的外科医生特定因素(并尽量减少患者相关因素),我们报告了年龄在65岁及以下、术前性功能正常且接受保留神经的机器人辅助腹腔镜根治性前列腺切除术患者的2年性功能恢复情况。

材料与方法

2004年7月至2006年2月期间,1名外科医生为200例患者实施了机器人辅助腹腔镜根治性前列腺切除术。纳入标准为年龄65岁及以下,国际勃起功能指数5项指标的基线评分为22至25分且正常,并有完整的2年随访资料。术后性功能恢复情况通过前瞻性自我填写的有效问卷进行定义,问卷询问“勃起是否足以进行阴道性交”以及“勃起是否满意”,无论是否使用5型磷酸二酯酶药物。患者还报告了国际勃起功能指数5项指标的评分以及与术前相比勃起饱满度为0%至10%、25%、50%、75%或100%的情况。

结果

共有62例患者符合纳入标准,其中3例失访,1例因接受激素治疗被排除在研究之外。3个月时,32.1%的患者报告性功能恢复。24个月时,总体性功能恢复率为89.7%(58例中的52例),双侧保留神经的患者为93.0%(43例中的40例),单侧保留神经的患者为80.0%(15例中的12例)。性功能恢复的患者在3个月时国际勃起功能指数5项指标的平均评分为20.4,24个月时为21.3。与术前基线相比,24个月时平均勃起硬度为91%,52例中有34例(65%)报告勃起饱满度达到术前的100%。单侧保留神经和双侧保留神经的患者在24个月时国际勃起功能指数5项指标的评分及饱满度相当。

结论

总体而言,90%的患者在24个月时报告性功能恢复,46%的患者国际勃起功能指数5项指标评分正常且勃起硬度达到100%,恢复至基线水平。值得注意的是,单侧保留神经和双侧保留神经的患者在国际勃起功能指数5项指标评分或饱满度方面没有差异。

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