半乳糖凝集素-2 3279TT变异体可预防与淋巴毒素-α 252GG基因型相关的缺血性中风。

Galectin-2 3279TT variant protects against the lymphotoxin-alpha 252GG genotype associated ischaemic stroke.

作者信息

Szolnoki Zoltan, Maasz Anita, Magyari Lili, Horvatovich Katalin, Farago Bernadett, Kondacs Andras, Bodor Anita, Hadarits Ferenc, Orosz Peter, Ille Alexandru, Melegh Bela

机构信息

Department of Cerebrovascular Disease, Pandy Kalman County Hospital, Gyula, Hungary.

出版信息

Clin Neurol Neurosurg. 2009 Apr;111(3):227-30. doi: 10.1016/j.clineuro.2008.09.027. Epub 2008 Nov 14.

DOI:10.1016/j.clineuro.2008.09.027

PMID:19013708

Abstract

OBJECTIVE

The galectin-2 protein is presumed to play a regulatory role in the intracellular trafficking of the lymphotoxin-alpha (LTA) cytokine. LTA is a pro-inflammatory factor, its 252GG homozygote variant is considered as a susceptibility factor for arteriosclerosis and cardiovascular diseases. By contrast, the galectin-2-encoding gene LGALS2 3279TT homozygote variant has been demonstrated to exert protection against myocardial infarction by reducing the transcriptional level of galectin-2, thereby leading to a reduced extracellular secretion of LTA.

METHODS

In the present study, we examined whether the LGALS2 3279TT homozygote variant alone can influence the prevalence of ischaemic stroke, and whether it can interact somehow with the disadvantageous LTA 252GG homozygote variant. Genetic and clinical data of 385 ischemic stroke patients and 303 stroke and neuroimaging alteration-free controls were analysed.

RESULTS

The combination of the LGALS2 3279TT and LTA 252GG homozygote was significantly less frequent in the ischemic stroke group (1.56%) than in the controls (5.94%, p<0.00187; overall stroke group: crude OR: 0.25, 95% CI: 0.1-0.64; adjusted OR: 0.03, 95% CI: 0.025-0.71).

CONCLUSIONS

This finding suggests a gene-gene interaction.

摘要

目的

据推测，半乳糖凝集素-2蛋白在淋巴毒素-α（LTA）细胞因子的细胞内运输中起调节作用。LTA是一种促炎因子，其252GG纯合子变体被认为是动脉粥样硬化和心血管疾病的易感因素。相比之下，已证明编码半乳糖凝集素-2的基因LGALS2 3279TT纯合子变体通过降低半乳糖凝集素-2的转录水平来预防心肌梗死，从而减少LTA的细胞外分泌。