Radfar Lida, Fatahzadeh Mahnaz
Department of Oral Medicine, University of Oklahoma College of Dentistry, Oklahoma City, USA.
Gen Dent. 2008 Nov-Dec;56(7):714-8.
Neuroendocrine (NE) carcinoma is a rare disease originating from the NE cell system, which is considered to be the third division of the nervous system. Based on their biological characteristics, NE carcinomas are classified into three subtypes: well-differentiated NE carcinoma (typical carcinoid tumor), moderately differentiated NE carcinoma (atypical carcinoid tumor), and poorly differentiated carcinoma (small cell carcinoma). Among the primary tumors, the propensity for disease to spread to the oral region varies. Although metastatic oral disease is rare, dentists should be aware of such a possibility, particularly when examining patients with a known history of malignancy. This case report describes a patient with an unknown primary NE malignancy that led to metastatic lesions in both the liver and mandibular soft tissues.
神经内分泌（NE）癌是一种起源于NE细胞系统的罕见疾病，NE细胞系统被认为是神经系统的第三部分。根据其生物学特性，NE癌可分为三种亚型：高分化NE癌（典型类癌肿瘤）、中分化NE癌（非典型类癌肿瘤）和低分化癌（小细胞癌）。在原发性肿瘤中，疾病扩散至口腔区域的倾向各不相同。虽然口腔转移疾病很少见，但牙医应意识到这种可能性，尤其是在检查有已知恶性肿瘤病史的患者时。本病例报告描述了一名原发性NE恶性肿瘤不明的患者，该肿瘤导致肝脏和下颌软组织出现转移病灶。
