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口腔黏膜神经内分泌细胞及相关恶性肿瘤:综述。

Neuroendocrine cells and associated malignancies of the oral mucosa: a review.

机构信息

Division of Oral Pathology, School of Oral Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

出版信息

J Oral Pathol Med. 2010 Feb;39(2):121-7. doi: 10.1111/j.1600-0714.2009.00834.x. Epub 2009 Dec 8.

Abstract

Neuroendocrine cells of the oral mucosa constitute an under-recognized component of the diffuse neuroendocrine system with diverse subpopulations and elusive biologic roles in the oral cavity. Primary malignant oral tumors that show a neuroendocrine phenotype display histomorphologic heterogeneity thereby giving rise to a spectrum of lesions in this rare category of oral malignancy. These lesions can be divided into neuroendocrine carcinomas (NECs) of small cell or non-small cell type. The former is further subdivided into the Merkel cell type or the pulmonary type while the latter includes atypical carcinoid tumor and large cell NEC. All histologic subtypes of oral NEC appear to have a strong predilection for men in their fifth or sixth decade and arise predominantly in the non-keratinized oral mucosa. The biologic behavior of oral Merkel cell carcinomas appears to be more aggressive than those of skin. It remains to be determined whether histologic categorization of the remaining tumor subtypes is predictive of patient survival in oral neuroendocrine tumors.

摘要

口腔黏膜神经内分泌细胞构成弥散性神经内分泌系统中一个未被充分认识的组成部分,具有多种亚群,在口腔中具有难以捉摸的生物学作用。表现出神经内分泌表型的原发性口腔恶性肿瘤具有组织形态学异质性,从而导致此类罕见口腔恶性肿瘤中出现一系列病变。这些病变可分为小细胞或非小细胞型神经内分泌癌 (NEC)。前者进一步细分为 Merkel 细胞型或肺型,而后者包括非典型类癌和大细胞 NEC。口腔 NEC 的所有组织学亚型似乎都强烈偏爱 50 或 60 岁的男性,主要发生在非角化口腔黏膜。口腔 Merkel 细胞癌的生物学行为似乎比皮肤更具侵袭性。尚不确定剩余肿瘤亚型的组织学分类是否可预测口腔神经内分泌肿瘤患者的生存。

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