Carlsen B C, Fischer L A, Sosted H, Vølund A, Menné T, Johansen J D
Department of Dermatology and Allergology, National Allergy Research Centre, Copenhagen University Hospital Gentofte, Ledreborg Allé 40, 1., 2820 Gentofte, Denmark.
Br J Dermatol. 2009 Jan;160(1):103-6. doi: 10.1111/j.1365-2133.2008.08921.x. Epub 2008 Nov 11.
It is not known if reduced elicitation thresholds are evident among polysensitized individuals when using allergens to which the patients are already sensitized. Reduced elicitation thresholds may be an expression of increased reactivity in this patient group.
To examine and compare elicitation dose-response curves and elicitation thresholds in a polysensitized vs. a single/double-sensitized group for allergens to which the test subjects were already sensitized.
PATIENTS/METHODS: Fifty-one patients (13 polysensitized and 38 single/double-sensitized) were patch tested with nickel sulphate, methyldibromo glutaronitrile (MDBGN) and p-phenylenediamine (PPD) in dilution series. The ratio between the doses eliciting a response in 50% of patients in the two groups was used as the measure for relative sensitivity.
The dose-response curves of the polysensitized group for MDBGN and PPD were shifted to the right, and for nickel sulphate shifted to the left, compared with the single/double-sensitized group. The relative sensitivity for each of the three allergens and a combined relative sensitivity for all three allergens were not significantly different when comparing the polysensitized and single/double-sensitized groups.
No increased sensitivity, in the form of distinct elicitation thresholds, could be demonstrated in polysensitized individuals compared with individuals with one or two contact allergies.
尚不清楚在使用患者已经致敏的变应原时，多敏化个体的激发阈值是否降低。激发阈值降低可能是该患者群体反应性增加的一种表现。
检查并比较多敏化组与单敏化/双敏化组对于受试对象已经致敏的变应原的激发剂量-反应曲线和激发阈值。
患者/方法：51例患者（13例多敏化患者和38例单敏化/双敏化患者）用硫酸镍、甲基二溴戊二腈（MDBGN）和对苯二胺（PPD）的稀释系列进行斑贴试验。两组中引起50%患者出现反应的剂量之比用作相对敏感性的度量。
与单敏化/双敏化组相比，多敏化组对MDBGN和PPD的剂量-反应曲线右移，对硫酸镍的剂量-反应曲线左移。比较多敏化组和单敏化/双敏化组时，三种变应原各自的相对敏感性以及所有三种变应原的综合相对敏感性无显著差异。
与有一或两种接触性过敏的个体相比，多敏化个体未表现出以明显激发阈值形式存在的敏感性增加。
