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本文引用的文献

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Urinary eosinophil-derived neurotoxin concentrations in patients with atopic dermatitis: a useful clinical marker for disease activity.特应性皮炎患者尿中嗜酸性粒细胞衍生神经毒素浓度：疾病活动度的有用临床标志物。
Allergol Int. 2007 Dec;56(4):433-8. doi: 10.2332/allergolint.O-07-489. Epub 2007 Nov 1.
2
Eosinophil cationic protein (ECP) polymorphisms and association with asthma, s-ECP levels and related phenotypes.嗜酸性粒细胞阳离子蛋白（ECP）多态性及其与哮喘、可溶性ECP水平及相关表型的关联。
Allergy. 2007 Apr;62(4):429-36. doi: 10.1111/j.1398-9995.2007.01327.x.
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The genetics of atopic dermatitis.特应性皮炎的遗传学
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A (G->C) transversion in the 3' UTR of the human ECP (eosinophil cationic protein) gene correlates to the cellular content of ECP.人类嗜酸性粒细胞阳离子蛋白（ECP）基因3'非翻译区的A（G->C）颠换与ECP的细胞含量相关。
J Leukoc Biol. 2006 Apr;79(4):846-51. doi: 10.1189/jlb.0904517. Epub 2006 Jan 24.
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Genetic polymorphisms of eosinophil-derived neurotoxin and eosinophil cationic protein in tropical pulmonary eosinophilia.热带肺嗜酸性粒细胞增多症中嗜酸性粒细胞衍生神经毒素和嗜酸性粒细胞阳离子蛋白的基因多态性
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Eosinophils and atopic dermatitis.嗜酸性粒细胞与特应性皮炎。
Allergy. 2004 Jun;59(6):561-70. doi: 10.1111/j.1398-9995.2004.00476.x.
8
Clinical phenotypes of asthma.哮喘的临床表型
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Incidence and remission of asthma: a retrospective study on the natural history of asthma in Italy.哮喘的发病率与缓解情况：意大利哮喘自然史的回顾性研究
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10
Polymorphism of the eosinophil cationic protein-gene is related to the expression of allergic symptoms.嗜酸性粒细胞阳离子蛋白基因的多态性与过敏症状的表达有关。
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德国特应性皮炎患者中嗜酸性粒细胞颗粒蛋白编码基因的变异

Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany.

作者信息

Parwez Qumar, Stemmler Susanne, Epplen Jörg T, Hoffjan Sabine

机构信息

Department of Human Genetics, Ruhr-University, Bochum, Germany.

出版信息

J Negat Results Biomed. 2008 Nov 13;7:9. doi: 10.1186/1477-5751-7-9.

DOI:10.1186/1477-5751-7-9
PMID:19014520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2596079/
Abstract

BACKGROUND

Atopic dermatitis (AD) is believed to result from complex interactions between genetic and environmental factors. A main feature of AD as well as other allergic disorders is serum and tissue eosinophilia. Human eosinophils contain high amounts of cationic granule proteins, including eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), eosinophil peroxidase (EPO) and major basic protein (MBP). Recently, variation in genes encoding eosinophil granule proteins has been suggested to play a role in the pathogenesis of allergic disorders. We therefore genotyped selected single nucleotide polymorphisms within the ECP, EDN, EPO and MBP genes in a cohort of 361 German AD patients and 325 healthy controls.

RESULTS

Genotype and allele frequencies did not differ between patients and controls for all polymorphisms investigated in this study. Haplotype analysis did not reveal any additional information.

CONCLUSION

We did not find evidence to support an influence of variation in genes encoding eosinophil granule proteins for AD pathogenesis in this German cohort.

摘要

背景

特应性皮炎（AD）被认为是由遗传和环境因素之间的复杂相互作用所致。AD以及其他过敏性疾病的一个主要特征是血清和组织嗜酸性粒细胞增多。人类嗜酸性粒细胞含有大量阳离子颗粒蛋白，包括嗜酸性粒细胞阳离子蛋白（ECP）、嗜酸性粒细胞衍生神经毒素（EDN）、嗜酸性粒细胞过氧化物酶（EPO）和主要碱性蛋白（MBP）。最近，有研究表明编码嗜酸性粒细胞颗粒蛋白的基因变异在过敏性疾病的发病机制中起作用。因此，我们对361名德国AD患者和325名健康对照组成的队列中的ECP、EDN、EPO和MBP基因内选定的单核苷酸多态性进行了基因分型。

结果

本研究中所调查的所有多态性的基因型和等位基因频率在患者和对照之间没有差异。单倍型分析未发现任何其他信息。

结论

在这个德国队列中，我们没有发现证据支持编码嗜酸性粒细胞颗粒蛋白的基因变异对AD发病机制有影响。