Aigner Felix, Aigner Wolfgang, Hoppichler Friedrich, Luef Gerhard, Bonatti Hugo
Department of Surgery, University of Virginia health services, Charlottesville, VA, USA.
Cases J. 2008 Nov 14;1(1):312. doi: 10.1186/1757-1626-1-312.
Antiepileptic drug induced hypersensitivity syndrome is a rare side effect of some of the first line anticonvulsive drugs such as carbamazepine and other aromatic agents. We are the first to mention a rare case of gastrointestinal, skin and cardiac findings related to carbamazepine administration, which is very uncommon and needs to be reported.
We report on a 62-year-old Caucasian woman with carbamazepine associated hypersensitivity syndrome, who developed diarrhea, fever, skin lesions, pericardial effusion and pathology on electrocardiogram with terminal negative T waves in I, II, aVL, V5 and V6,. After withdrawal of carbamazepine and administration of methylprednisolone, all initial symptoms improved, white blood cell count normalized, pericardial effusion resolved and pathologic electrocardiogram findings resolved.
Anticonvulsive drug hypersensitivity syndromes can present with a wide spectrum of unspecific symptoms, which the prescribing clinician should be aware of.
抗癫痫药物引起的超敏反应综合征是某些一线抗惊厥药物（如卡马西平和其他芳香族药物）罕见的副作用。我们首次提及一例与卡马西平给药相关的罕见病例，该病例出现胃肠道、皮肤和心脏方面的症状，极为罕见，需要报告。
我们报告一名62岁的白种女性，患有卡马西平相关超敏反应综合征，出现腹泻、发热、皮肤病变、心包积液以及心电图异常，表现为I、II、aVL、V5和V6导联T波终末倒置。停用卡马西平并给予甲泼尼龙后，所有初始症状均有改善，白细胞计数恢复正常，心包积液消退，心电图异常表现也消失。
抗惊厥药物超敏反应综合征可表现出多种非特异性症状，开处方的临床医生应予以关注。
