1例与卡马西平治疗相关的药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征。
A case of DRESS syndrome associated with carbamazepine treatment.
作者信息
Dursun Adem, Bayram Ayşe Kaçar, Tekerek Nazan Ülgen, Akyıldız Başak Nur, Per Hüseyin
机构信息
Erciyes University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Intensive Care, Kayseri, Turkey.
Erciyes University, Faculty of Medicine, Department of Pediatrics, Division of Pediatric Neurology, Kayseri, Turkey.
出版信息
Turk Pediatri Ars. 2018 Mar 1;53(1):48-50. doi: 10.5152/TurkPediatriArs.2017.3671. eCollection 2018 Mar.
Abstract
Fever and rash associated in a wide clinical spectrum, drug rash with eosiophilia and systemic symptoms syndrome (DRESS) is a potentially life-threatening hypersensitivity reaction. Early diagnosis and treatment and removal of the offending agent can be life-saving. Physicians should be aware of DRESS syndrome, particularly in patients receiving antiepileptic medication and admitted with a symptoms of fever and skin rash. In this study, a girl aged three years who had been under carbamazepine therapy for one month was admitted to our hospital with symptoms of fever and rash and was diagnosed as having DRESS syndrome, is presented to increase awareness of DRESS syndrome among physicians.
摘要
发热与皮疹在广泛的临床谱中相关联，药物超敏反应伴嗜酸性粒细胞增多和全身症状综合征（DRESS）是一种潜在的危及生命的超敏反应。早期诊断、治疗以及去除致病药物可挽救生命。医生应了解DRESS综合征，尤其是在接受抗癫痫药物治疗且伴有发热和皮疹症状入院的患者中。在本研究中，一名3岁女童接受卡马西平治疗1个月后因发热和皮疹症状入院，被诊断为患有DRESS综合征，现予以报道以提高医生对DRESS综合征的认识。
相似文献
1
A case of DRESS syndrome associated with carbamazepine treatment.1例与卡马西平治疗相关的药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征。
Turk Pediatri Ars. 2018 Mar 1;53(1):48-50. doi: 10.5152/TurkPediatriArs.2017.3671. eCollection 2018 Mar.
2
Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) induced by carbamazepine: a case report and literature review.卡马西平诱发的药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）：一例报告及文献复习
Pan Afr Med J. 2014 May 2;18:9. doi: 10.11604/pamj.2014.18.9.3799. eCollection 2014.
3
Patch testing is an effective method for the diagnosis of carbamazepine-induced drug reaction, eosinophilia and systemic symptoms (DRESS) syndrome in an 8-year-old girl.斑贴试验是诊断 1 例 8 岁女童卡马西平诱导的药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征的有效方法。
Australas J Dermatol. 2012 Nov;53(4):274-7. doi: 10.1111/j.1440-0960.2012.00887.x. Epub 2012 Apr 24.
4
Drug hypersensitivity to previously tolerated phenytoin by carbamazepine-induced DRESS syndrome.卡马西平诱发的药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征导致对先前耐受的苯妥英钠产生药物超敏反应。
J Korean Med Sci. 2006 Aug;21(4):768-72. doi: 10.3346/jkms.2006.21.4.768.
5
Carbamazepine-induced DRESS syndrome leading to reversible myocarditis in a child.卡马西平诱发的药物超敏反应综合征导致一名儿童出现可逆性心肌炎。
Cent Eur J Immunol. 2019;44(1):102-105. doi: 10.5114/ceji.2019.83700. Epub 2019 Apr 15.
6
[Skin reaction to carbamazepine or DRESS syndrome: a case presentation].[卡马西平引起的皮肤反应或药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征：病例报告]
Medwave. 2016 Feb 25;16(1):e6389. doi: 10.5867/medwave.2016.01.6389.
7
Sulthiame-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.舒噻美诱发的药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征。
Eur J Paediatr Neurol. 2016 Nov;20(6):957-961. doi: 10.1016/j.ejpn.2016.07.023. Epub 2016 Aug 1.
8
Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Induced by Levetiracetam in a Pediatric Patient.左乙拉西坦诱发小儿患者的药物反应伴嗜酸性粒细胞增多和全身症状综合征
J Emerg Med. 2016 Feb;50(2):e61-6. doi: 10.1016/j.jemermed.2015.10.004. Epub 2015 Nov 18.
9
Phenytoin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a case report from the emergency department.苯妥英钠诱发的伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）综合征：来自急诊科的病例报告
J Emerg Med. 2013 Jan;44(1):75-8. doi: 10.1016/j.jemermed.2011.05.052.
10
Pediatrician! Do you know the symptoms of DRESS syndrome? A case report of a 4-year-old girl.儿科医生！你知道药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征的症状吗？一名4岁女孩的病例报告。
Pediatr Emerg Care. 2013 Apr;29(4):504-7. doi: 10.1097/PEC.0b013e31828a3854.
引用本文的文献
1
Carbamazepine-Induced DRESS Syndrome During Epstein-Barr Virus Reactivation in an Adolescent.青少年爱泼斯坦-巴尔病毒再激活期间卡马西平诱发的药物超敏反应伴嗜酸性粒细胞增多和系统症状综合征
J Pediatr Pharmacol Ther. 2025 Jun;30(3):372-375. doi: 10.5863/JPPT-24-00015. Epub 2025 Jun 9.
2
Does sensitization by SARS-CoV-2 immune complexes trigger DRESS syndrome?严重急性呼吸综合征冠状病毒2型免疫复合物致敏会引发药物超敏反应伴嗜酸性粒细胞增多和系统症状（DRESS）综合征吗？
Braz J Infect Dis. 2022 Mar-Apr;26(2):102337. doi: 10.1016/j.bjid.2022.102337. Epub 2022 Feb 28.
3
Drug reaction with eosinophilia and systemic symptoms (DRESS) in children.儿童药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）
Acta Biomed. 2019 Jan 29;90(3-S):66-79. doi: 10.23750/abm.v90i3-S.8167.
本文引用的文献
1
Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome Induced by Levetiracetam in a Pediatric Patient.左乙拉西坦诱发小儿患者的药物反应伴嗜酸性粒细胞增多和全身症状综合征
J Emerg Med. 2016 Feb;50(2):e61-6. doi: 10.1016/j.jemermed.2015.10.004. Epub 2015 Nov 18.
2
Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome.药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）综合征
J Clin Aesthet Dermatol. 2013 Jun;6(6):31-7.
3
Drug reaction with eosinophilia and systemic symptoms (DRESS): an original multisystem adverse drug reaction. Results from the prospective RegiSCAR study.药物反应伴嗜酸性粒细胞增多和全身症状（DRESS）：一种原始的多系统药物不良反应。来自前瞻性 RegiSCAR 研究的结果。
Br J Dermatol. 2013 Nov;169(5):1071-80. doi: 10.1111/bjd.12501.
4
Anticonvulsant hypersensitivity syndrome: an update.抗惊厥药物过敏反应综合征：最新进展。
Expert Opin Drug Saf. 2012 Sep;11(5):767-78. doi: 10.1517/14740338.2012.705828. Epub 2012 Jul 14.
5
Drug reaction with Eosinophilia and Systemic Symptoms (DRESS) / Drug-induced Hypersensitivity Syndrome (DIHS): a review of current concepts.药物超敏反应伴嗜酸性粒细胞增多和全身症状（DRESS）/药物性超敏反应综合征（DIHS）：当前概念综述
An Bras Dermatol. 2012 May-Jun;87(3):435-49. doi: 10.1590/s0365-05962012000300013.
6
Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpesvirus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review.药物诱导的超敏反应综合征（DIHS）是由人类疱疹病毒 6 感染引起，还是由过敏介导的病毒再激活引起？病例报告及文献复习。
BMC Infect Dis. 2010 Mar 6;10:49. doi: 10.1186/1471-2334-10-49.
7
Carbamazepine-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: report of four cases and brief review.卡马西平诱发的伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS）综合征：4例报告及简要综述
Int J Dermatol. 2008 Aug;47(8):853-60. doi: 10.1111/j.1365-4632.2008.03637.x.
8
Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses.药物性超敏反应综合征（DIHS）：一种由疱疹病毒、抗病毒及抗药物免疫反应之间复杂相互作用引发的反应。
Allergol Int. 2006 Mar;55(1):1-8. doi: 10.2332/allergolint.55.1.
9
Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS).药物性假性淋巴瘤和药物超敏反应综合征（药物疹伴嗜酸性粒细胞增多和全身症状：DRESS）。
Semin Cutan Med Surg. 1996 Dec;15(4):250-7. doi: 10.1016/s1085-5629(96)80038-1.
10
Anticonvulsant hypersensitivity syndrome.抗惊厥药超敏反应综合征
Arch Intern Med. 1995 Nov 27;155(21):2285-90.
Zotero 插件