Ginieri-Coccossis M, Theofilou P, Synodinou C, Tomaras V, Soldatos C
1st Department of Psychiatry, Medical School, University of Athens, Athens, Greece.
BMC Nephrol. 2008 Nov 14;9:14. doi: 10.1186/1471-2369-9-14.
The study examines differences regarding quality of life (QoL), mental health and illness beliefs between in-centre haemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD/PD) patients. Differences are examined between patients who recently commenced treatment compared to patients on long term treatment.
144 End-Stage Renal Disease (ESRD) patients were recruited from three treatment units, of which 135 provided full data on the variables studied. Patients consisted of: a) 77 in-centre haemodialysis (HD) and 58 continuous ambulatory peritoneal dialysis (CAPD/PD) patients, all currently being treated by dialysis for varied length of time. Patients were compared for differences after being grouped into those who recently commenced treatment (< 4 years) and those on long term treatment (> 4 years). Next, cases were selected as to form two equivalent groups of HD and CAPD/PD patients in terms of length of treatment and sociodemographic variables. The groups consisted of: a) 41 in-centre haemodialysis (HD) and b) 48 continuous ambulatory peritoneal dialysis (CAPD/PD) patients, fitting the selection criteria of recent commencement of treatment and similar sociodemographic characteristics. Patient-reported assessments included: WHOQOL-BREF, GHQ-28 and the MHLC, which is a health locus of control inventory.
Differences in mean scores were mainly observed in the HD patients with > 4 years of treatment, providing lower mean scores in the QoL domains of physical health, social relationships and environment, as well as in overall mental health. Differences in CAPD/PD groups, between those in early and those in later years of treatment, were not found to be large and significant. Concerning the analysis on equivalent groups derived from selection of cases, HD patients indicated significantly lower mean scores in the QoL domain of environment and higher scores in the GHQ-28 subscales of anxiety/insomnia and severe depression, indicating more symptoms in these areas of mental health. With regards to illness beliefs, HD patients who recently commenced treatment provided higher mean scores in the dimension of internal health locus of control, while CAPD/PD patients on long term treatment indicated higher mean scores in the dimension of chance. Regarding differences in health beliefs between equivalent groups of HD and CAPD/PD patients, HD patients focused more on the dimension of internal health locus of control.
The results provide evidence that patients in HD treatment modality, particularly those with many years of treatment, were experiencing a more compromised QoL in comparison to CAPD/PD patients.
本研究探讨了中心血液透析(HD)患者与持续性非卧床腹膜透析(CAPD/PD)患者在生活质量(QoL)、心理健康和疾病认知方面的差异。同时还比较了近期开始治疗的患者与长期治疗患者之间的差异。
从三个治疗单位招募了144例终末期肾病(ESRD)患者,其中135例提供了所研究变量的完整数据。患者包括:a)77例中心血液透析(HD)患者和58例持续性非卧床腹膜透析(CAPD/PD)患者,所有患者目前均接受不同时长的透析治疗。将患者分为近期开始治疗(<4年)和长期治疗(>4年)两组后,比较两组间的差异。接下来,根据治疗时长和社会人口统计学变量,选取病例组成两组HD和CAPD/PD的等效组。这两组包括:a)41例中心血液透析(HD)患者和b)48例持续性非卧床腹膜透析(CAPD/PD)患者,符合近期开始治疗且社会人口统计学特征相似的选择标准。患者报告的评估包括:世界卫生组织生活质量简表(WHOQOL-BREF)、一般健康问卷-28项(GHQ-28)以及多维健康控制点量表(MHLC)。
平均得分差异主要出现在治疗超过4年的HD患者中,他们在身体健康、社会关系和环境等生活质量领域以及整体心理健康方面的平均得分较低。未发现CAPD/PD组中早期和晚期治疗患者之间的差异有显著意义。关于从病例选择中得出的等效组分析,HD患者在环境生活质量领域的平均得分显著较低,在GHQ-28焦虑/失眠和重度抑郁子量表中的得分较高,表明在这些心理健康领域存在更多症状。关于疾病认知,近期开始治疗的HD患者在内因健康控制点维度上的平均得分较高,而长期治疗的CAPD/PD患者在机遇维度上的平均得分较高。关于HD和CAPD/PD等效组患者在健康认知方面的差异,HD患者更关注内因健康控制点维度。
结果表明,与CAPD/PD患者相比,接受HD治疗方式的患者,尤其是那些接受多年治疗的患者,生活质量受到更大影响。