Kutner Nancy G, Zhang Rebecca, Barnhart Huiman, Collins Allan J
USRDS Rehabilitation/QoL Special Studies Center, Emory University, CRM-1441 Clifton Road NE, Atlanta, GA 30322, USA.
Nephrol Dial Transplant. 2005 Oct;20(10):2159-67. doi: 10.1093/ndt/gfh973. Epub 2005 Jul 26.
It has been suggested that there are no large differences in the quality of life of incident patients starting on haemodialysis (HD) and peritoneal dialysis (PD), but few studies have addressed this issue.
Association of modality with incident patients' health status and quality of life scores was investigated with propensity score (PS) analysis and also with traditional multivariable regression analyses. We compared patient reported health status and quality of life scores after 1 year of therapy in 455 HD and 413 PD patients who participated in a national study, stayed on the same modality and had complete socio-demographic and clinical information needed to create a PS indicating their expected probability of starting on PD.
One year scores on the majority of health status and quality of life measures were not significantly different for HD and PD patients within propensity-matched quintiles. PD patients' scores were higher than HD patients' scores on effects of kidney disease, burden of kidney disease, staff encouragement and satisfaction with care in some quintiles, and traditional regression analyses confirmed that dialysis modality was associated with patients' scores on these variables.
This study provides support for making the choice of PD more widely available as an option to patients initiating chronic dialysis therapy. Patient lifestyle opportunities associated with use of PD, a home-based and self-care therapy, may also apply to home-based HD or in-centre self-care HD. Patients' expectations regarding treatment and their attitudes toward management of their health may interact with treatment modality to shape patient-reported experience on dialysis; this is an important focus for future studies.
有观点认为,开始接受血液透析(HD)和腹膜透析(PD)的初发患者在生活质量方面并无显著差异,但很少有研究探讨这一问题。
采用倾向评分(PS)分析以及传统多变量回归分析,研究透析方式与初发患者健康状况及生活质量评分之间的关联。我们比较了参与一项全国性研究、维持相同透析方式且拥有创建PS所需完整社会人口统计学和临床信息(以表明其开始接受PD的预期概率)的455例HD患者和413例PD患者在治疗1年后患者报告的健康状况及生活质量评分。
在倾向匹配五分位数内,HD和PD患者在大多数健康状况和生活质量指标上的1年评分无显著差异。在某些五分位数中,PD患者在肾病影响、肾病负担、医护鼓励及护理满意度方面的评分高于HD患者,传统回归分析证实透析方式与患者在这些变量上的评分相关。
本研究为更广泛地向开始慢性透析治疗的患者提供PD选择提供了支持。与采用居家自我护理治疗的PD相关的患者生活方式机会,也可能适用于居家HD或中心自我护理HD。患者对治疗的期望及其对健康管理的态度可能与治疗方式相互作用,从而塑造患者报告的透析体验;这是未来研究的一个重要重点。