Fagerlund Birgitte, Glenthøj Birte Y
Børne-ungdomspsykiatrisk Center, Bispebjerg Hospital, DK-2100 København Ø.
Ugeskr Laeger. 2008 Nov 10;170(46):3770-2.
Cognitive deficits are vulnerability indicators for psychotic disorders, particularly schizophrenia. The deficits remain stable throughout the illness in schizophrenia, but fluctuate with clinical state in other psychotic disorders. They are limiting factors for patients' prognoses and there is considerable incentive to develop treatments that can improve these deficits. The current brief review summarizes the relevance of cognitive deficits for the pathogenesis and prognosis of psychotic disorders, and identifies pertinent issues within the research field.
认知缺陷是精神障碍尤其是精神分裂症的脆弱性指标。在精神分裂症中，这些缺陷在疾病全过程中保持稳定，但在其他精神障碍中会随临床状态波动。它们是影响患者预后的限制因素，因此有相当大的动力去开发能够改善这些缺陷的治疗方法。本简要综述总结了认知缺陷与精神障碍发病机制及预后的相关性，并确定了该研究领域内的相关问题。
