青霉胺诱发威尔逊病患儿及威尔逊病母亲所生健康婴儿的甲状腺功能减退和激素合成障碍。

Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease.

作者信息

Hanukoglu Aaron, Curiel Batya, Berkowitz Drora, Levine Arieh, Sack Joseph, Lorberboym Mordehai

机构信息

Division of Pediatric Endocrinology, E. Wolfson Medical Center, Holon, Israel; Tel-Aviv University, Sackler School of Medicine, Israel.

出版信息

J Pediatr. 2008 Dec;153(6):864-6. doi: 10.1016/j.jpeds.2008.06.015.

DOI:10.1016/j.jpeds.2008.06.015

PMID:19014823

Abstract

Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.

摘要

一位患有威尔逊氏病且正在服用D-青霉胺的母亲所生的两名兄弟姐妹患了短暂性甲状腺肿性甲状腺功能减退症。对5名服用和未服用D-青霉胺长达9.5年的威尔逊氏病患者进行的前瞻性评估显示有亚临床甲状腺功能减退。D-青霉胺可能在健康婴儿的子宫内以及威尔逊氏病患者的儿童期抑制了甲状腺过氧化物酶的活性。