C57/B6小鼠肝脏发育过程中基因表达和转录调控的多阶段分析
Multi-stage analysis of gene expression and transcription regulation in C57/B6 mouse liver development.
作者信息
Li Tingting, Huang Jian, Jiang Ying, Zeng Yan, He Fuchu, Zhang Michael Q, Han Zeguang, Zhang Xuegong
机构信息
TNLIST/Department of Automation, MOE Key Laboratory of Bioinformatics and Bioinformatics Division, Tsinghua University, Beijing, China.
出版信息
Genomics. 2009 Mar;93(3):235-42. doi: 10.1016/j.ygeno.2008.10.006. Epub 2008 Dec 10.
Abstract
The liver performs a number of essential functions for life. The development of such a complex organ relies on finely regulated gene expression profiles which change over time in the development and determine the phenotype and function of the liver. We used high-density oligonucleotide microarrays to study the gene expression and transcription regulation at 14 time points across the C57/B6 mouse liver development, which include E11.5 (embryonic day 11.5), E12.5, E13.5, E14.5, E15.5, E16.5, E17.5, E18.5, Day0 (the day of birth), Day3, Day7, Day14, Day21, and normal adult liver. With these data, we made a comprehensive analysis on gene expression patterns, functional preferences and transcriptional regulations during the liver development. A group of uncharacterized genes which might be involved in the fetal hematopoiesis were detected.
摘要
肝脏执行许多维持生命所必需的功能。如此复杂的器官的发育依赖于精细调控的基因表达谱，这些表达谱在发育过程中随时间变化，并决定肝脏的表型和功能。我们使用高密度寡核苷酸微阵列研究了C57/B6小鼠肝脏发育过程中14个时间点的基因表达和转录调控，这些时间点包括E11.5（胚胎第11.5天）、E12.5、E13.5、E14.5、E15.5、E16.5、E17.5、E18.5、出生日（Day0）、出生后第3天、第7天、第14天、第21天以及正常成年肝脏。利用这些数据，我们对肝脏发育过程中的基因表达模式、功能偏好和转录调控进行了全面分析。检测到一组可能参与胎儿造血的未表征基因。
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