Ohana Ehud, Yang Dongki, Shcheynikov Nikolay, Muallem Shmuel
Department of Physiology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390-9040, USA.
J Physiol. 2009 May 15;587(Pt 10):2179-85. doi: 10.1113/jphysiol.2008.164863. Epub 2008 Nov 17.
The solute carrier 26 (SLC26) transporters are anion transporters with diverse substrate specificity. Several members are ubiquitous while others show limited tissue distribution. They are expressed in many epithelia and to the extent known, play a central role in anion secretion and absorption. Members of the family are primarily Cl- transporters, although some members transport mainly SO(4)2-, Cl-, HCO(3)- or I-. A defining feature of the family is their functional diversity. Slc26a1 and Slc26a2 function as specific SO(4)2- transporters while Slc26a4 functions as an electroneutral Cl-/I-/HCO(3)- exchanger. Slc26a3 and Slc26a6 function as coupled electrogenic Cl-/HCO(3)- exchangers or as bona fide anion channels. SLC26A7 and SLC26A9 function exclusively as Cl- channels. This short review discusses the functional diversity of the SLC26 transporters.
溶质载体26（SLC26）转运蛋白是具有多种底物特异性的阴离子转运蛋白。其中几个成员分布广泛，而其他成员的组织分布有限。它们在许多上皮组织中表达，并且就目前所知，在阴离子分泌和吸收中起核心作用。该家族成员主要是氯离子转运蛋白，尽管有些成员主要转运硫酸根离子（SO(4)2-）、氯离子、碳酸氢根离子（HCO(3)-）或碘离子。该家族的一个决定性特征是其功能多样性。Slc26a1和Slc26a2作为特定的硫酸根离子转运蛋白发挥作用，而Slc26a4作为电中性的氯离子/碘离子/碳酸氢根离子交换体发挥作用。Slc26a3和Slc26a6作为偶联的电生性氯离子/碳酸氢根离子交换体或真正的阴离子通道发挥作用。SLC26A7和SLC26A9仅作为氯离子通道发挥作用。本简短综述讨论了SLC26转运蛋白的功能多样性。
