Hartzell H Criss, Yu Kuai, Xiao Qinhuan, Chien Li-Ting, Qu Zhiqiang
Department of Cell Biology, Emory University School of Medicine, 615 Michael Street, 535 Whitehead Bldg, Atlanta, GA 30322, USA.
J Physiol. 2009 May 15;587(Pt 10):2127-39. doi: 10.1113/jphysiol.2008.163709. Epub 2008 Nov 17.
Ca(2+)-activated Cl- channels (CaCCs) perform many important functions in cell physiology including secretion of fluids from acinar cells of secretory glands, amplification of olfactory transduction, regulation of cardiac and neuronal excitability, mediation of the fast block to polyspermy in amphibian oocytes, and regulation of vascular tone. Although a number of proteins have been proposed to be responsible for CaCC currents, the anoctamin family (ANO, also known as TMEM16) exhibits characteristics most similar to those expected for the classical CaCC. Interestingly, this family of proteins has previously attracted the interest of both developmental and cancer biologists. Some members of this family are up-regulated in a number of tumours and functional deficiency in others is linked to developmental defects.
钙离子激活的氯离子通道（CaCCs）在细胞生理学中发挥着许多重要功能，包括分泌腺泡状细胞分泌液体、嗅觉转导放大、心脏和神经元兴奋性调节、两栖类卵母细胞对多精受精的快速阻断介导以及血管张力调节。尽管已有多种蛋白质被认为与CaCC电流有关，但anoctamin家族（ANO，也称为TMEM16）表现出与经典CaCC最为相似的特征。有趣的是，该蛋白质家族此前已引起发育生物学家和癌症生物学家的关注。该家族的一些成员在多种肿瘤中上调，而其他成员的功能缺陷则与发育缺陷有关。
