Zhang Y X, Neu H C
Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
Diagn Microbiol Infect Dis. 1991 Jan-Feb;14(1):23-7. doi: 10.1016/0732-8893(91)90083-r.
We determined the effect of the combination of rifampin and fleroxacin against Enterobacteriaceae and streptococcal species. None of the 65 isolates tested by checkerboard assay demonstrated synergy, 12% of isolates showed an additive effect; 86.7% were indifferent, and only 1 isolate showed antagonism. The mean FIC was 1.2. When using 2 and 8 micrograms/ml of rifampin, fleroxacin MICs of 285 isolates of Enterobacteriaceae, Pseudomonas aeruginosa, Haemophilus influenzae, staphylococci, streptococci, Bacteroides, and Clostridium were not increased, but synergy was not demonstrated. Time-kill studies against Escherichia coli, P. aeruginosa, Enterobacter cloacae, Staphylococcus aureus, and Enterococcus faecalis failed to show increased killing when the two agents were present at one-half the MBC. The fleroxacin-rifampin interaction is one of indifference but provides coverage for species not adequately inhibited by fleroxacin.
我们测定了利福平与氟罗沙星联合使用对肠杆菌科细菌和链球菌属细菌的作用。通过棋盘法检测的65株分离菌中，无一表现出协同作用，12%的分离菌表现出相加作用；86.7%无作用，仅1株分离菌表现出拮抗作用。平均FIC为1.2。当使用2微克/毫升和8微克/毫升的利福平时，285株肠杆菌科细菌、铜绿假单胞菌、流感嗜血杆菌、葡萄球菌、链球菌、拟杆菌属和梭菌属细菌的氟罗沙星MIC未升高，但未显示出协同作用。针对大肠杆菌、铜绿假单胞菌、阴沟肠杆菌、金黄色葡萄球菌和粪肠球菌的时间杀菌研究表明，当两种药物浓度为MBC的一半时，未显示出杀菌作用增强。氟罗沙星与利福平的相互作用是无作用，但可覆盖氟罗沙星抑制效果不佳的菌种。
