将利福平添加到青霉素、头孢曲松或氧氟沙星中对肺炎链球菌的体外抗菌作用。
In vitro antimicrobial effect against Streptococcus pneumoniae of adding rifampin to penicillin, ceftriaxone, or 1-ofloxacin.
作者信息
Giron K P, Gross M E, Musher D M, Williams T W, Tharappel R A
机构信息
Medical Science, Infectious Disease Section, Veterans Affairs Medical Center, Houston, Texas 77030, USA.
出版信息
Antimicrob Agents Chemother. 1995 Dec;39(12):2798-800. doi: 10.1128/AAC.39.12.2798.
Abstract
Adding rifampin to penicillin or l-ofloxacin diminished the rate at which these antibiotics killed 21 clinical isolates isolates of Streptococcus pneumoniae in vitro. A less pronounced inhibitory effect was observed when rifampin was added to ceftriaxone. Synergy was not observed for any bacterial isolate. The in vitro demonstration of indifference or antagonism using these antibiotic combinations argues against the empirical addition of rifampin to beta-lactams or fluoroquinolones in treating serious pneumococcal infections.
摘要
在青霉素或左氧氟沙星中加入利福平会降低这些抗生素在体外杀死21株肺炎链球菌临床分离株的速率。当利福平加入头孢曲松时，观察到的抑制作用不太明显。对于任何细菌分离株均未观察到协同作用。使用这些抗生素组合在体外证明无作用或拮抗作用，反对在治疗严重肺炎球菌感染时凭经验将利福平添加到β-内酰胺类或氟喹诺酮类药物中。
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