Perez-Garrigues Herminio, Lopez-Escamez Jose A, Perez Paz, Sanz Ricardo, Orts Miguel, Marco Jaime, Barona Rafael, Tapia Mari C, Aran Ismael, Cenjor Carlos, Perez Nicolas, Morera Constantino, Ramirez Rafael
Division of Otoneurology, Department of Otorhinolaryngology, Hospital Universitario La Fe, Passeig de la Sequia 12, 46111 Rocafort, Valencia, Spain.
Arch Otolaryngol Head Neck Surg. 2008 Nov;134(11):1149-54. doi: 10.1001/archotol.134.11.1149.
To evaluate the frequency and duration of episodes of definitive vertigo in Ménière's disease.
Prospective longitudinal study.
Multiple tertiary referral centers.
Five hundred ten individuals from 8 hospitals that met the American Academy of Otolaryngology-Head and Neck Surgery diagnostic criteria for definitive Ménière's disease.
Conservative treatment.
Frequency and duration of episodes of definitive vertigo during follow-up.
Ménière's disease affects both sexes and both ears equally, with onset generally in the fourth decade of life. The number of episodes of vertigo is greater in the first few years of the disease. Although episodes of vertigo that last longer than 6 hours are less frequent than shorter episodes, they occur with similar frequency throughout the natural course of the disease. The percentage of patients without episodes of vertigo increases as the disease progresses, and 70% of patients who did not have an episode of vertigo for 1 year will continue to be free of episodes during the following year. Thus, there is a relationship between the frequency of episodes in consecutive years, although this association decreases rapidly as the number of years increases.
The frequency of definitive episodes of vertigo in Ménière's disease decreased during follow-up, and many individuals reached a steady-state phase free of vertigo.
评估梅尼埃病中明确眩晕发作的频率和持续时间。
前瞻性纵向研究。
多个三级转诊中心。
来自8家医院的510名个体，符合美国耳鼻咽喉头颈外科学会明确梅尼埃病的诊断标准。
保守治疗。
随访期间明确眩晕发作的频率和持续时间。
梅尼埃病对男女及双耳的影响相同，发病通常在生命的第四个十年。在疾病的最初几年，眩晕发作的次数较多。虽然持续时间超过6小时的眩晕发作比持续时间较短的发作频率低，但在疾病的自然病程中，它们出现的频率相似。随着疾病进展，无眩晕发作的患者百分比增加，1年内无眩晕发作的患者中有70%在次年仍将无发作。因此，连续几年发作频率之间存在关联，尽管随着年份增加这种关联迅速减弱。
在随访期间，梅尼埃病中明确眩晕发作的频率降低，许多个体进入无眩晕的稳定期。
