Manrique Tatiana, Gámiz Fernando, Morón Ignacio, Ballesteros M Angeles, Gallo Milagros
Institute of Neurosciences F. Oloriz., University of Granada, Granada, Spain.
Dev Psychobiol. 2009 Mar;51(2):147-57. doi: 10.1002/dev.20354.
The ontogeny of the temporal context modulation of conditioned taste aversion was studied in male Wistar rats using a palatable 1% NaCl solution. A procedure that included two saline preexposures, a single pairing saline-lithium chloride (0.15 M; 1% b.w.) either at the same or a different time of day of preexposures and a one-bottle test at the same time than preexposure was applied. Four age groups (PN32, PN48, PN64, and PN100) covering the complete range from adolescence to the adult period were tested. The results showed no effect of a temporal context shift in PN32. A peculiar enhancement of temporal context-specific saline aversions was exhibited by PN48 and PN64 rats, while the adult typical temporal context specificity of latent inhibition was only evident in PN100 rats. The results are discussed in terms of the peculiar brain functional organization during a protracted adolescence period.
利用可口的1%氯化钠溶液，在雄性Wistar大鼠中研究了条件性味觉厌恶的时间背景调节的个体发生。采用了一种程序，包括两次生理盐水预暴露、在预暴露的同一天或不同时间进行一次生理盐水与氯化锂（0.15 M；1%体重）的配对，以及在与预暴露相同的时间进行单瓶测试。测试了涵盖从青春期到成年期完整范围的四个年龄组（出生后第32天、第48天、第64天和第100天）。结果表明，在出生后第32天，时间背景转移没有影响。出生后第48天和第64天的大鼠表现出时间背景特异性生理盐水厌恶的特殊增强，而成人典型的潜在抑制时间背景特异性仅在出生后第100天的大鼠中明显。根据青春期延长期间特殊的大脑功能组织对结果进行了讨论。
