Burns Ted M, Conaway Mark R, Cutter Gary R, Sanders Donald B
University of Virginia, Department of Neurology, Charlottesville, Virginia 22908, USA.
Muscle Nerve. 2008 Dec;38(6):1553-62. doi: 10.1002/mus.21185.
We assessed the performance of items from the Quantitative Myasthenia Gravis (QMG), MMT (Manual Muscle Test), and MG-ADL (Myasthenia Gravis - Activities of Daily Living) scales, using data from two recently completed treatment trials of generalized MG. Items were selected that were relevant to manifestations of MG, meaningful to both the physician and the patient, and responsive to clinical change. After the 10 items were chosen, they were weighted based on input from MG experts from around the world, considering factors such as quality of life, disease severity, risk, prognosis, validity, and reliability. The MG Composite is easy to administer, takes less than 5 minutes to complete, and requires no equipment. Weighting of the response options of the 10 items should result in ordinal scores that better represent MG status and are more responsive to meaningful clinical change. To better determine its suitability for clinical use and for treatment trials, the MG Composite will be tested prospectively at several academic medical centers and will be used as a secondary measure of efficacy in pending clinical trials of MG.
我们利用两项近期完成的全身性重症肌无力治疗试验的数据，评估了重症肌无力定量评分（QMG）、徒手肌力测试（MMT）和重症肌无力日常生活活动量表（MG-ADL）中各项条目的性能。所选条目与重症肌无力的表现相关，对医生和患者都有意义，并且能对临床变化做出反应。在选定这10个条目后，根据来自世界各地的重症肌无力专家的意见进行加权，同时考虑生活质量、疾病严重程度、风险、预后、效度和信度等因素。重症肌无力综合量表易于实施，完成时间不到5分钟，且无需设备。对这10个条目的应答选项进行加权应能得出更能代表重症肌无力状态且对有意义的临床变化更敏感的等级评分。为了更好地确定其在临床应用和治疗试验中的适用性，重症肌无力综合量表将在多个学术医学中心进行前瞻性测试，并将在即将开展的重症肌无力临床试验中用作疗效的次要衡量指标。
