Verweij K J H, Zietsch B P, Bailey J M, Martin N G
Genetic Epidemiology, Queensland Institute of Medical Research, 300 Herston Road, Brisbane, QLD 4029, Australia.
Genes Brain Behav. 2009 Feb;8(1):107-13. doi: 10.1111/j.1601-183X.2008.00456.x.
Risky sexual behaviour (RSB) is a major risk factor for serious diseases as well as unplanned pregnancy. It is not known if RSB has a genetic basis or if it is only influenced by social and cultural conditions. Adolescent conduct disorder has previously been linked to RSB and has been found to be influenced by both genetic and environmental factors. In this study, we look at normal variation in a broad measure of RSB and in retrospectively reported adolescent misconduct in a large community sample of twins (n = 4904) to partition the variance and covariance between the traits into genetic and environmental components. We found that RSB is influenced to the same extent by genes, shared environment and unshared environment. Adolescent misconduct is moderately influenced by genetic factors and only modestly by shared environmental factors. Moreover, RSB is associated with adolescent misconduct (r = 0.5), primarily because of genetic correlation between the variables. The implications of our findings as well as possible sex differences are discussed.
危险的性行为（RSB）是导致严重疾病以及意外怀孕的主要风险因素。目前尚不清楚RSB是否具有遗传基础，或者它是否仅受社会和文化条件的影响。青少年品行障碍此前已与RSB相关联，并且已发现它受到遗传和环境因素的共同影响。在本研究中，我们观察了一大群双胞胎（n = 4904）的RSB广泛测量指标以及回顾性报告的青少年不当行为的正常变异情况，以将这些性状之间的方差和协方差划分为遗传和环境成分。我们发现，RSB受基因、共享环境和非共享环境的影响程度相同。青少年不当行为受遗传因素的影响适中，受共享环境因素的影响较小。此外，RSB与青少年不当行为相关（r = 0.5），主要是因为变量之间的遗传相关性。我们讨论了研究结果的意义以及可能存在的性别差异。
