Tanahashi Jin, Kashima Kenji, Daa Tsutomu, Yada Naomi, Fujiwara Sakuhei, Yokoyama Shigeo
Department of Pathology, Faculty of Medicine, Oita University, Yufu, Oita, Japan.
J Cutan Pathol. 2009 Sep;36(9):983-6. doi: 10.1111/j.1600-0560.2008.01160.x. Epub 2008 Nov 9.
Merkel cell carcinoma is occasionally associated with other types of cutaneous malignancies including squamous cell carcinoma, basal cell carcinoma and lentigo maligna. We report a case of Merkel cell carcinoma co-existent with sebaceous carcinoma in the right upper eyelid of a 61-year-old Japanese man. Histopathologically, the resected tumor consisted of three nodules located in the tarsal plate, showing two distinct histopathological types. Two nodules were Merkel cell carcinoma and located in the proximal part of the palpebral conjunctiva. The third was sebaceous carcinoma located in the distal transitional zone between the epidermis and the conjunctiva. No features of transition between these two components were noted. Metastatic deposits were identified in the regional lymph nodes, which solely consisted of Merkel cell carcinoma without sebaceous carcinoma. This is the first report of such co-existent lesions.
默克尔细胞癌偶尔与其他类型的皮肤恶性肿瘤相关，包括鳞状细胞癌、基底细胞癌和恶性雀斑样痣。我们报告了一例61岁日本男性右上眼睑默克尔细胞癌与皮脂腺癌共存的病例。组织病理学上，切除的肿瘤由位于睑板的三个结节组成，呈现两种不同的组织病理学类型。两个结节为默克尔细胞癌，位于睑结膜近端。第三个是皮脂腺癌，位于表皮和结膜之间的远端过渡区。未发现这两种成分之间的过渡特征。在区域淋巴结中发现转移灶，其仅由默克尔细胞癌组成，无皮脂腺癌成分。这是此类共存病变的首例报告。
